Workshop

研讨会
  • 文章类型: Journal Article
    背景:尽管护理过程有许多优点,护理专业的学生经常为使用这种模式而苦苦挣扎。因此,研究提出了解决这一问题的创新教学方法。基于真实临床案例的教学被认为是一种协作学习方法,可以增强学生的主动学习,以培养批判性思维和解决问题的能力。在这种方法中,学生可以通过访问真实的信息来获得关于病人护理的足够知识。
    目的:本研究的目的是调查护理学生和教职员工在实施护理过程教育研讨会方面的经验,基于真实的案例研究。
    方法:定性描述性研究。
    方法:9名护理学生和7名来自伊斯法罕护理和助产学院的教职员工参加了研讨会。
    方法:这项定性的描述性研究于2021年至2023年进行。数据是通过半结构化的个人和焦点小组访谈收集的,使用定性内容分析方法进行数据分析。
    结果:分析数据后,确定了一个名为“打破护理过程中的禁忌”的主题。这个主题包括四个类别:“加强接受护理过程的认知基础设施,“”增强护理过程的适用性,\"\"协助积极的职业身份,\"和\"促进自我指导的学习平台。\"此外,获得了13个子类别。
    结论:从本研究获得的数据表明,开展护理过程教育研讨会,讨论真正的临床病例,分析,和批评,增加批判性思维,学习动机,了解实施护理过程的必要性和重要性。因此,建议教师利用这种创新有效的教学方法指导护理过程。
    BACKGROUND: Despite the numerous advantages of the nursing process, nursing students often struggle with utilizing this model. Therefore, studies suggest innovative teaching methods to address this issue. Teaching based on real clinical cases is considered a collaborative learning method that enhances students\' active learning for the development of critical thinking and problem-solving skills. In this method, students can acquire sufficient knowledge about patient care by accessing authentic information.
    OBJECTIVE: The aim of the present study was to investigate the experiences of nursing students and faculty members regarding the implementation of nursing process educational workshops, based on real case studies.
    METHODS: A qualitative descriptive study.
    METHODS: 9 Nursing students and 7 faculty members from the Isfahan School of Nursing and Midwifery who attended the workshops.
    METHODS: This qualitative descriptive study was conducted from 2021 to 2023. Data was collected through semi-structured individual and focus group interviews using a qualitative content analysis approach for data analysis.
    RESULTS: After analyzing the data, a theme titled \"Breaking Taboos in the Nursing Process\" was identified. This theme consists of four categories: \"Strengthening the Cognitive Infrastructure for Accepting the Nursing Process,\" \"Enhancing the Applicability of the Nursing Process,\" \"Assisting in Positive Professional Identity,\" and \"Facilitating a Self-Directed Learning Platform.\" Additionally, thirteen subcategories were obtained.
    CONCLUSIONS: The data obtained from the present study showed that conducting nursing process educational workshops, where real clinical cases are discussed, analyzed, and criticized, increases critical thinking, learning motivation, and understanding of the necessity and importance of implementing the nursing process. Therefore, it is recommended that instructors utilize this innovative and effective teaching method for instructing the nursing process.
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  • 文章类型: Journal Article
    背景:肿瘤患者有很高的信息需求,但往往得不到满足。患者版本的肿瘤临床实践指南(PVG)将临床实践指南翻译成外行语言,可能有助于满足患者的信息需求。目前,30个肿瘤PVG已在德国出版,更多的正在开发中。在德国进行了一个关于肿瘤PVGs的大型多阶段项目之后,多方利益攸关方研讨会通过了改进PVG使用和传播的建议。
    方法:代表PVG用户的组织(患者,医务人员,和乘数),创造者,PVG的发起人/资助组织,邀请在制定临床实践指南或患者健康信息方面具有方法学专业知识的组织参加。讲习班包括一个世界咖啡馆,用于讨论预选建议和所有建议的结构化共识程序。同意>75%的建议获得批准,在≤75%协议的情况下,建议被拒绝。
    结果:研讨会于2023年4月24日在科隆举行,德国。总的来说,来自24个组织的23人参加了讨论。在35项建议中,有28项建议达成共识并获得批准。这些建议提到了主题传播(N=13),设计和格式(N=7),(数字)链接(N=5),数字化(N=4),最新(N=3),以及在医疗保健提供者和患者之间的合作中使用PVG(N=3)。
    结论:实际建议考虑了各种观点,可以帮助改善肿瘤PVG在德国的使用和传播。纳入不同的利益攸关方可以促进将结果转化为实践。
    BACKGROUND: Oncological patients have high information needs that are often unmet. Patient versions of oncological clinical practice guidelines (PVG) translate clinical practice guidelines into laypersons\' language and might help to address patients\' information needs. Currently, 30 oncological PVG have been published in Germany and more are being developed. Following a large multi-phase project on oncological PVGs in Germany, recommendations to improve use and dissemination of PVG were adopted in a multi-stakeholder workshop.
    METHODS: Organisations representing users of PVGs (patients, medical personnel, and multipliers), creators, initiators/funding organisations of PVGs, and organisations with methodological expertise in the development of clinical practice guidelines or in patient health information were invited to participate. The workshop included a World Café for discussion of pre-selected recommendations and structured consensus procedure for of all recommendations. Recommendations with agreement of > 75% were approved, and in case of ≤ 75% agreement, recommendations were rejected.
    RESULTS: The workshop took place on 24th April 2023 in Cologne, Germany. Overall, 23 people from 24 organisations participated in the discussion. Of 35 suggested recommendations 28 recommendations reached consensus and were approved. The recommendations referred to the topics dissemination (N = 13), design and format (N = 7), (digital) links (N = 5), digitalisation (N = 4), up-to-dateness (N = 3), and use of the PVG in collaboration between healthcare providers and patients (N = 3).
    CONCLUSIONS: The practical recommendations consider various perspectives and can help to improve use and dissemination of oncological PVG in Germany. The inclusion of different stakeholders could facilitate the transfer of the results into practice.
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  • 文章类型: Journal Article
    心理健康干预措施可以帮助减轻个人在科学,技术,Engineering,和数学(STEM)面对这些学科。我们开发了“心理健康与健康:我们的社区和我们在STEM中的身份”研讨会,强调利用我们的STEM社区和促进自我同情,促进STEM社区成员之间关于如何支持心理健康和健康的对话。这个互动研讨会从一个简短的讲座开始,以定义心理健康和健康,并介绍基于证据的方法来增加自我同情。参与者,他们通常来自不同的背景和不同的职业阶段,然后探索案例研究,强调跨STEM职业阶段与心理健康相关的经验。研讨会参与者的前后评估表明,参与者对自己表现出同情心的能力发生了积极的变化,并且在他们的STEM社区内讨论心理健康时感到更加舒适。这次研讨会不仅为参与者提供了实用的工具和见解,而且还培养了一个支持性的环境,强调STEM领域内心理健康意识和集体福祉的重要性。在本文中,我们分享这个研讨会是如何执行的技巧,以及我们从更广泛的STEM社区分享类似研讨会的经验。我们希望本文可以为潜在的主持人提供宝贵的指导,以在各自的STEM空间中开展有关心理健康和健康的对话。
    Mental health interventions can help mitigate the unique challenges that individuals in Science, Technology, Engineering, and Mathematics (STEM) face as they navigate these disciplines. We developed the \"Mental Health and Wellness: Our Community and our Identity in STEM\" workshop, which emphasizes leveraging our STEM community and promoting self-compassion, to foster a conversation among members of the STEM community on how to support mental health and wellness. This interactive workshop begins with a short lecture to define mental health and wellness and introduce evidence-based methods to increase self-compassion. Participants, who are often from diverse backgrounds and various career stages, then explore case studies that highlight experiences related to mental health across STEM career stages. Pre- and post-assessments of workshop participants suggest that participants had positive shifts in their ability to show compassion toward themselves as well as an increased comfort in discussing mental health within their STEM community. This workshop not only provided participants with practical tools and insights but also cultivated a supportive environment, underscoring the importance of mental health awareness and collective well-being within STEM fields. In this paper, we share tips on how this workshop was executed and lessons we have learned from our years of sharing similar workshops in the broader STEM community. We hope this paper serves as a valuable guide for potential facilitators to initiate conversations about mental health and wellness in their respective STEM spaces.
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  • 文章类型: Journal Article
    文化意识辅导(CAM)研讨会的开发是为了帮助生物医学教师获得意识和技能,以更有效地与种族和种族少数民族学员合作。本文的目的是介绍一项国家集群随机比较研究的评估结果,其中CAM以在线格式提供。我们评估了这项研究的主要数据,其中包括来自12所大学的231名生物医学教师。总的来说,参与者对在线互动干预的呈现方式和内容进行了良好的评价,报告帮助他们成为一个更有文化意识的导师。他们进一步建议如何改进讲习班。我们讨论了对导师实践者的影响和未来的研究方向。
    The Culturally Aware Mentoring (CAM) workshop was developed to help biomedical faculty gain awareness and skills to work more effectively with racially and ethnically minoritized mentees. The purpose of this paper is to present evaluation findings from a national cluster randomized comparative study in which CAM was delivered in an online format. We evaluated data from the primary arm of this study, which included 231 biomedical faculty from 12 universities. Overall, participants evaluated both the presentation and content of the online interactive intervention favorably, reporting it helped them become a more culturally aware mentor. They further suggested how the workshop may be improved. We discuss implications for mentorship practitioners and future research directions.
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  • 文章类型: Journal Article
    胃肠病学监管终点和治疗学发展VI研讨会,2021年7月22日举行,为患者和学术界代表提供了一个论坛,工业,患者倡导团体,和食品和药物管理局讨论乳糜泻(CeD)的药物开发。研讨会的重点是临床试验中组织学评估的方法,儿科药物开发的考虑因素,以及在临床试验中使用面筋攻击(GC)。鉴于目前尚未在临床试验中广泛接受组织学评分系统,早期临床试验应理想地探索各种组织学尺度,并评估CeD的组织学发现,作为指导未来试验的个别指标.在计划CeD的儿科药物开发时,适当使用从适当的疗效数据外推,在成人中进行的良好对照研究有助于儿科患者及时获得安全有效的治疗.确定适合目的的儿科临床结果评估可以进一步促进儿科药物开发。对GC的组织学反应取决于暴露,剂量,和持续时间;短期暴露似乎不会导致长期后果。然而,应以深思熟虑的方式将GC纳入临床试验,以产生可解释的结果并确保患者安全。所有利益相关者之间的持续合作将有助于开发安全有效的CeD疗法。
    The Gastroenterology Regulatory Endpoints and the Advancement of Therapeutics VI Workshop, held on July 22, 2021, provided a forum for patients and representatives from academia, industry, patient advocacy groups, and Food and Drug Administration to discuss drug development for celiac disease (CeD). The workshop focused on the approach of histologic assessments in clinical trials, considerations for pediatric drug development, and the use of a gluten challenge (GC) in clinical trials. Given that no histologic scoring system is widely accepted for use in clinical trials at this time, early-phase clinical trials should ideally explore a variety of histologic scales and assess the histologic findings of CeD as individual measures to inform future trials. When planning pediatric drug development in CeD, appropriate use of extrapolation of efficacy data from adequate, well-controlled studies in adults could facilitate timely access to safe and effective therapies for pediatric patients. Identification of a fit-for-purpose pediatric clinical outcome assessment could further advance pediatric drug development. Histologic responses to the GC depend on exposure, dose, and duration; short exposures do not appear to cause long-term consequences. However, the GC should be incorporated into clinical trials in a thoughtful manner to generate interpretable results and ensure patient safety. Ongoing collaboration between all stakeholders will facilitate the development of safe and effective therapeutics for CeD.
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  • 文章类型: Journal Article
    精通医学写作和出版对于医学研究人员至关重要。讲习班可以在解决这些问题方面发挥重要作用。然而,缺乏评估其影响的系统证据摘要。所以,在这次系统审查中,我们的目标是评估全球范围内发表的关于此类研讨会影响的所有文章。
    我们搜索了OvidEMBASE,OvidMedline,ISIWebofScience,ERIC数据库,没有语言的灰色文学,时间段,或地理位置限制。随机对照试验,队列研究,前后研究,调查,包括项目评估和开发研究。我们在研讨会后对与知识增长相关的数据进行了荟萃分析,并描述性地报告了对其他没有足够数据进行荟萃分析的文章的评估。所有分析均使用Stata软件进行,版本15.0。
    在23040份报告中,222篇文章进行了全文审查,导致45篇文章报告研讨会的影响。总的来说,关于此类讲习班影响的报告不完整或缺乏必要的准确性,无法得出可接受的结论。讲习班是零星的,研究人员使用了他们自己的评估方法。对知识影响的荟萃分析表明,研讨会可以不显著增加参与者知识的平均值或百分比。
    在缺乏关于医学写作/出版的系统学术课程的情况下,研讨会在世界各地举办;然而,关于此类讲习班期间教育活动的报告,介绍的方法,他们的课程不完整且各不相同。它们的影响没有使用标准化方法进行评估,这些评估没有采用有效和可靠的测量工具。
    UNASSIGNED: Proficiency in medical writing and publishing is essential for medical researchers. Workshops can play a valuable role in addressing these issues. However, there is a lack of systematic summaries of evidence on the evaluation of their impacts. So, in this systematic review, we aimed to evaluate all articles published on the impact of such workshops worldwide.
    UNASSIGNED: We searched Ovid EMBASE, Ovid Medline, ISI Web of Science, ERIC database, and grey literature with no language, time period, or geographical location limitations. Randomized controlled trials, cohort studies, before-after studies, surveys, and program evaluation and development studies were included. We performed a meta-analysis on data related to knowledge increase after the workshops and descriptively reported the evaluation of other articles that did not have sufficient data for a meta-analysis. All analyses were performed using Stata software, version 15.0.
    UNASSIGNED: Of 23 040 reports, 222 articles underwent full-text review, leading to 45 articles reporting the impacts of workshops. Overall, the reports on the impact of such workshops were incomplete or lacked the necessary precision to draw acceptable conclusions. The workshops were sporadic, and researchers used their own method of assessment. Meta-analyses of the impact on the knowledge showed that workshops could nonsignificantly increase the mean or percentage of participants\' knowledge.
    UNASSIGNED: In the absence of systematic academic courses on medical writing/publishing, workshops are conducted worldwide; however, reports on educational activities during such workshops, the methods of presentations, and their curricula are incomplete and vary. Their impact is not evaluated using standardized methods, and no valid and reliable measurement tools have been employed for these assessments.
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  • 文章类型: Journal Article
    饮食,还有整体的食物环境,包括对人类健康有直接和间接影响的各种重要因素。生态区是以地域方式进行农村发展的地理区域,利用有机食品和农业实践,和原则,并促进可持续社区和粮食系统。然而,到目前为止,很少注意量化生活在这些可持续过渡地区的公民的健康方面。项目“可持续消费对健康影响评估指标”,在生态区域的有机学校餐(INSUM)旨在确定和讨论研究方法和指标,可用于有效地测量身体,心理,和生态区域公民的社会健康维度,与他们饮食中有机食品的摄入量有关。在本文中,我们专注于身体(身体)健康维度。举行了为期两天的研讨会,以跨学科的方式讨论合适的方法,国际专家组。结果显示了常用的测量饮食摄入量的工具的局限性(例如,依靠参与者的记忆),和营养生物标志物(例如,与特定摄入量的相关性变化),以了解饮食摄入量和饮食对健康的影响。为了调查这个问题的复杂性,最合适的方法似乎是将传统的身体和心理健康标记与微生物组等新兴指标相结合,营养基因组学,代谢组学,或炎性生物标志物。使用新的,数字,非侵入性,和可穿戴技术来监测指标可以补充未来的研究。我们得出结论,未来的研究应该采用系统性的,多学科方法,不仅结合躯体和心理健康和社会福祉(MHSW)的指标,而且考虑有机饮食对健康的潜在益处以及与食物环境相关的可持续性方面。
    Diets, but also overall food environments, comprise a variety of significant factors with direct and indirect impacts on human health. Eco-Regions are geographical areas with a territorial approach to rural development, utilizing organic food and farming practices, and principles and promoting sustainable communities and food systems. However, so far, little attention has been given to quantifying aspects of the health of citizens living in these sustainable transition territories. The project \"Indicators for Assessment of Health Effects of Consumption of Sustainable, Organic School Meals in Eco-Regions\" (INSUM) aims to identify and discuss research approaches and indicators that could be applied to effectively measure the somatic, mental, and social health dimensions of citizens in Eco-Regions, linked to the intake of organic foods in their diets. In this paper, we focus on the somatic (physical) health dimension. A two-day workshop was held to discuss suitable methodology with an interdisciplinary, international group of experts. The results showed the limitations of commonly used tools for measuring dietary intake (e.g., relying on the memory of participants), and nutritional biomarkers (e.g., variations in correlations with specific intakes) for research understanding dietary intake and the health effects of diets. To investigate the complexity of this issue, the most suitable approach seems to be the combination of traditional markers of physical and mental health alongside emerging indicators such as the microbiome, nutrigenomics, metabolomics, or inflammatory biomarkers. Using new, digital, non-invasive, and wearable technologies to monitor indicators could complement future research. We conclude that future studies should adopt systemic, multidisciplinary approaches by combining not only indicators of somatic and mental health and social wellbeing (MHSW) but also considering the potential benefits of organic diets for health as well as aspects of sustainability connected to food environments.
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  • 文章类型: Journal Article
    尽管许多国家的老年痴呆症患病率正在下降,最近的一些评论估计,拉丁美洲的患病率高于世界其他任何地方。这可能是,在某种程度上,由于该地区存在社会经济和健康相关危险因素的高发生率。然而,越来越多的证据表明,通过可改变的危险因素进行一级和二级预防是可能的,40%的病例可以通过针对可改变风险的干预措施得到缓解。这表明该地区可能存在降低痴呆症风险的显着空间。2021年6月,来自全球脑健康研究所(GBHI)的八名研究员主办了关于拉丁美洲脑健康和痴呆症预防挑战和机遇的专家共识研讨会。研讨会汇集了16位痴呆症专家,老化,以及来自一系列专业背景和地理区域的大脑健康。从本次研讨会中,我们整理了专家主导的共识,即在拉丁美洲背景下嵌入大脑健康和痴呆症预防计划所隐含的实际挑战和机遇。在这里,我们讨论这个研讨会的成果,强调几个挑战和机遇,并讨论如何应对这些挑战和机遇。
    While age-specific dementia prevalence is falling in many countries, several recent reviews estimate prevalence in Latin America to be higher than anywhere else in the world. This may be, in part, due to the high incidence of socioeconomic and health-related risk factors present in the region. However, growing evidence suggests that primary and secondary prevention via modifiable risk factors is possible, and that 40% of cases may be mitigated through interventions which target modifiable risk. This suggests that there may be significant scope for dementia risk reduction in this region. In June 2021, eight fellows from the Global Brain Health Institute (GBHI) hosted an expert consensus workshop on challenges and opportunities for brain health and dementia prevention in Latin America. The workshop brought together 16 experts in dementia, aging, and brain health from a range of professional backgrounds and geographical regions. From this workshop we collated an expert-led consensus regarding the practical challenges and opportunities implicit in embedding brain health and dementia prevention initiatives in the Latin American context. Here we discuss the outcomes of this workshop, highlighting several challenges and opportunities and discussing how these may be addressed.
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  • 文章类型: Evaluation Study
    初级创伤护理(PTC)课程最初是为在医疗资源有限的中低收入国家(LMICs)指导医护人员管理严重伤害患者而开发的。PTC已经教授了25年以上。许多研究表明,为期2天的PTC研讨会对一线卫生工作人员有用和提供信息,并有助于提高对创伤管理的知识和信心;然而,几乎没有证据表明该课程对临床实践变化的影响。柯克帕特里克模型(KM)和知识,态度,和实践(KAP)模型是评估该问题的有效方法。
    本研究的目的是调查为期2天的PTC课程如何影响满意度,知识,以及2家越南医院医护人员的技能,使用包含KAP模型和4级知识管理作为评估工具的概念框架。
    PTC课程分别于2022年2月和3月在ThanhHoa和NinhBinh医院的急诊科(ED)交付了2天。这项研究遵循了前瞻性的干预前后设计。我们使用经过验证的工具来评估参与者的满意度,知识,和技能之前,紧接着,课程交付后6个月。Fisher精确检验和Wilcoxon配对符号秩检验用于比较预测试的百分比和平均值,后测,以及课程参与者的6个月后随访时间点。
    共有80名医护人员参加了为期2天的PTC课程,近100%的参与者对课程感到满意。在知识管理(知识)的第2级,多项选择题和置信度矩阵的分数从60%显着提高到77%,从59%提高到71%,分别(P<.001),这些改善见于两个亚组(护士和医生).第三级的重点是练习,展示了一个显著的增量变化,场景检查表点从平均值5.9(SD1.9)增加到9.0(SD0.9),床旁临床检查表点从平均值5(SD1.5)增加到8.3(SD0.8)(均P<.001)。在6个月的随访中,多项选择题的分数,信心矩阵,和方案清单都保持不变,除了护士亚组的多项选择题得分(P=0.005)。
    在越南2家当地医院开展的PTC课程成功地证明了ED医护人员在3级知识管理方面的改进。信心矩阵和方案清单的改进在课程结束后至少保持了6个月。PTC课程应有效地提供和维持越南等其他低收入国家的知识和创伤护理实践的改进。
    UNASSIGNED: The Primary Trauma Care (PTC) course was originally developed to instruct health care workers in the management of patients with severe injuries in low- and middle-income countries (LMICs) with limited medical resources. PTC has now been taught for more than 25 years. Many studies have demonstrated that the 2-day PTC workshop is useful and informative to frontline health staff and has helped improve knowledge and confidence in trauma management; however, there is little evidence of the effect of the course on changes in clinical practice. The Kirkpatrick model (KM) and the knowledge, attitude, and practice (KAP) model are effective methods to evaluate this question.
    UNASSIGNED: The aim of this study was to investigate how the 2-day PTC course impacts the satisfaction, knowledge, and skills of health care workers in 2 Vietnamese hospitals using a conceptual framework incorporating the KAP model and the 4-level KM as evaluation tools.
    UNASSIGNED: The PTC course was delivered over 2 days in the emergency departments (EDs) of Thanh Hoa and Ninh Binh hospitals in February and March 2022, respectively. This study followed a prospective pre- and postintervention design. We used validated instruments to assess the participants\' satisfaction, knowledge, and skills before, immediately after, and 6 months after course delivery. The Fisher exact test and the Wilcoxon matched-pairs signed rank test were used to compare the percentages and mean scores at the pretest, posttest, and 6-month postcourse follow-up time points among course participants.
    UNASSIGNED: A total of 80 health care staff members attended the 2-day PTC course and nearly 100% of the participants were satisfied with the course. At level 2 of the KM (knowledge), the scores on multiple-choice questions and the confidence matrix improved significantly from 60% to 77% and from 59% to 71%, respectively (P<.001), and these improvements were seen in both subgroups (nurses and doctors). The focus of level 3 was on practice, demonstrating a significant incremental change, with scenarios checklist points increasing from a mean of 5.9 (SD 1.9) to 9.0 (SD 0.9) and bedside clinical checklist points increasing from a mean of 5 (SD 1.5) to 8.3 (SD 0.8) (both P<.001). At the 6-month follow-up, the scores for multiple-choice questions, the confidence matrix, and scenarios checklist all remained unchanged, except for the multiple-choice question score in the nurse subgroup (P=.005).
    UNASSIGNED: The PTC course undertaken in 2 local hospitals in Vietnam was successful in demonstrating improvements at 3 levels of the KM for ED health care staff. The improvements in the confidence matrix and scenarios checklist were maintained for at least 6 months after the course. PTC courses should be effective in providing and sustaining improvement in knowledge and trauma care practice in other LMICs such as Vietnam.
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  • 文章类型: Journal Article
    在紧急情况下实施脓毒症和脓毒性休克的生物标志物,仍然极具挑战性。这一观点源于一个为期3天的公私研讨会,旨在促进脓毒症生物标志物向临床实践的转变。作者由国际学术研究人员,临床医生科学家和行业专家组成,他们聚集了(i)以确定当前阻碍脓毒症生物标志物研究的障碍,(ii)概述生物标志物开发关键路径的重要里程碑;(iii)讨论生物标志物发现和实施的新途径。为了更适当地定义脓毒症中生物标志物的潜在位置,更好地了解败血症的病理生理学是强制性的,特别是脓毒症患者从早期炎症发作到晚期持续免疫抑制阶段的轨迹。这种随时间变化的宿主反应促使开发时间分辨测试以表征免疫功能障碍的持久性。此外,必须考虑成人和儿科脓毒症患者之间的年龄相关差异.在这种情况下,在实践中采用生物标志物的许多障碍,例如对诊断性能缺乏共识,缺乏对脓毒症生物标志物开发的严格建议,成本和资源影响,方法验证的挑战或有限的意识和教育已经确定。生物标志物指导的脓毒症干预措施,以确定将从治疗中受益更多的患者,如sTREM-1引导的Nangibotide治疗或肾上腺髓质素引导的Enibarcimab治疗,看起来很有希望,但需要进一步评估。通过分析大量复杂数据并识别复杂的多参数患者内生型或轨迹的能力,人工智能在脓毒症生物标志物发现领域也具有巨大潜力。最后,脓毒症的生物标志物开发需要(I)采用最先进的分析工具的全面和多学科的方法,(ii)创建一个协作融合科学和商业需求的平台,以及(iii)支持快速的监管审批程序。
    Implementation of biomarkers in sepsis and septic shock in emergency situations, remains highly challenging. This viewpoint arose from a public-private 3-day workshop aiming to facilitate the transition of sepsis biomarkers into clinical practice. The authors consist of international academic researchers and clinician-scientists and industry experts who gathered (i) to identify current obstacles impeding biomarker research in sepsis, (ii) to outline the important milestones of the critical path of biomarker development and (iii) to discuss novel avenues in biomarker discovery and implementation. To define more appropriately the potential place of biomarkers in sepsis, a better understanding of sepsis pathophysiology is mandatory, in particular the sepsis patient\'s trajectory from the early inflammatory onset to the late persisting immunosuppression phase. This time-varying host response urges to develop time-resolved test to characterize persistence of immunological dysfunctions. Furthermore, age-related difference has to be considered between adult and paediatric septic patients. In this context, numerous barriers to biomarker adoption in practice, such as lack of consensus about diagnostic performances, the absence of strict recommendations for sepsis biomarker development, cost and resources implications, methodological validation challenges or limited awareness and education have been identified. Biomarker-guided interventions for sepsis to identify patients that would benefit more from therapy, such as sTREM-1-guided Nangibotide treatment or Adrenomedullin-guided Enibarcimab treatment, appear promising but require further evaluation. Artificial intelligence also has great potential in the sepsis biomarker discovery field through capability to analyse high volume complex data and identify complex multiparametric patient endotypes or trajectories. To conclude, biomarker development in sepsis requires (i) a comprehensive and multidisciplinary approach employing the most advanced analytical tools, (ii) the creation of a platform that collaboratively merges scientific and commercial needs and (iii) the support of an expedited regulatory approval process.
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