目的:本系统综述支持WNT4基因参与子宫内膜异位症的病理生理学。
目的:基于多种族病例对照研究,对与子宫内膜异位症相关的WNT4rs7521902和rs16826658多态性进行系统评价和荟萃分析。
方法:使用Medline进行综合搜索,Embase,谷歌学者。
■用于使用布尔算子搜索的关键字是子宫内膜异位症,WNT4和多态性。这次审查遵循了PRISMA指南,在STATA18中进行荟萃分析。
结果:本综述中确定的WNT4多态性为rs7521902、rs16826658、rs2235529、rs3820282和rs12037376。
结果:通过数据库确定了总共250项研究;10项符合本综述的条件,其中8例纳入荟萃分析.在荟萃分析中分析了两个WNT4多态性(rs7521902和rs16826658)。在rs7521092多态性的CC基因型中,子宫内膜异位症的几率较低,合并OR为0.86(0.76,0.99)。大多数文章是高质量的病例对照研究,偏倚风险低。
结论:这项研究强调了WNT4多态性(rs7521092)与拉丁美洲子宫内膜异位症的关联,欧洲,和亚洲人口。
结论:人类基因组计划完成后,子宫内膜异位症的许多遗传方面被揭示,包括单核苷酸多态性(SNP)的发现。然而,由于缺乏重复和研究之间相互矛盾的结果,结论子宫内膜异位症遗传通路有待完成。WNT4的这一发现表明,即使在不同的种族中,它与子宫内膜异位症的关联也是有效的。表明了不同人群疾病的一般遗传方面。然而,需要进一步的研究来证实这一发现,包括功能生物学和纵向研究。
OBJECTIVE: This systematic review supports the involvement of the WNT4 gene in the pathophysiology of endometriosis.
OBJECTIVE: To conduct a systematic review and meta-analysis on WNT4 rs7521902 and rs16826658 polymorphism associated with endometriosis based on multi-ethnic case-control studies.
METHODS: Comprehensive searching was performed using Medline, Embase, and Google Scholar.
UNASSIGNED: Keywords used for searching using Boolean operators are endometriosis, WNT4, and polymorphism. This review followed PRISMA guidelines, and meta-analysis was conducted in STATA18.
RESULTS: WNT4 polymorphisms identified in this review were rs7521902, rs16826658, rs2235529, rs3820282, and rs12037376.
RESULTS: A total of 250 studies were identified through databases; 10 were eligible for this review, and eight were included in the meta-analysis. Two WNT4 polymorphisms (rs7521902 and rs16826658) were analysed in the meta-analysis. A lower risk of odds in having endometriosis was apparent in the CC genotype of rs7521092 polymorphism with a pooled OR of 0.86 (0.76, 0.99). Most articles were high-quality case-control studies and were at low risk of bias.
CONCLUSIONS: This study highlighted the association of WNT4 polymorphisms (rs7521092) and endometriosis across Latin America, Europe, and Asian populations.
CONCLUSIONS: Following the completion of the Human Genome Project, many genetic aspects of endometriosis were revealed, including the discovery of single nucleotide polymorphisms (SNPs). However, due to a lack of replications and conflicting results between studies, the conclusion of the endometriosis genetic pathway needed to be completed. This finding of WNT4 showed that its association with endometriosis was valid even in varied ethnicities, indicating a general genetic aspect of disease across populations. Nevertheless, further studies are needed to confirm this finding, including functional biological and longitudinal studies.