目的:研究膳食/血清支链氨基酸(BCAAs)与心脏代谢风险标志物之间的关系。
方法:在2791名参与者的队列中,在基线时,对所有参与者进行了两次饮食和心脏代谢风险标志物的测量,并在423名参与者的子集进行了1年后的测量.我们评估了基线时的血清BCAA和1年后的动脉僵硬度。饮食/血清BCAAs和心脏代谢风险标志物之间的横断面关联使用基线测量通过线性回归进行分析。而1年纵向关联采用线性混合效应回归的重复测量进行分析.
结果:家禽摄入较高的BCAA与较低的甘油三酯(β=-0.028,P=0.027)和较高的高密度脂蛋白胆固醇(HDL-C,β=0.013,P=0.006),而红色和加工肉或鱼中的BCAA与低密度脂蛋白胆固醇(β=0.025,P=0.001)和总胆固醇(β=0.012,P=0.033)呈负相关,分别。全谷物和坚果中的BCAAs与较高的HDL-C相关(β=0.011,P=0.016),降低TG(β=-0.021,P=0.041)和舒张压(β=-0.003,P=0.027)。此外,来自大豆或蔬菜和水果的BCAA与动脉僵硬度(β=-0.018,P=0.047)和收缩压(β=-0.011,P=0.003)呈负相关,分别。然而,精制谷物中的BCAAs与甘油三酸酯呈正相关(β=0.037,P=0.014)。总血清BCAAs与多种心脏代谢风险标志物不利相关(均P<0.05)。
结论:家禽的膳食BCAA,全谷物和坚果,大豆,蔬菜和水果可能是有利的,而BCAA在红色和加工肉类中,鱼,精制谷物与心脏代谢健康不利。血清BCAA显示与心脏代谢风险标志物的有害关联。
OBJECTIVE: To investigate the associations between dietary/serum branched-chain amino acids (BCAAs) and cardiometabolic risk markers.
METHODS: In a cohort of 2791 participants, diet and cardiometabolic risk markers were measured twice at baseline in overall participants and after 1-year in a subset of 423 participants. We assessed serum BCAAs at baseline and arterial stiffness after 1-year. The cross-sectional associations between dietary/serum BCAAs and cardiometabolic risk markers were analyzed using baseline measurements by linear regression, while the 1-year longitudinal association were analyzed using repeated measurements by linear mixed-effects regression.
RESULTS: Higher BCAA intake from poultry was associated with lower triglycerides (β=-0.028, P = 0.027) and higher high-density lipoprotein cholesterol (HDL-C, β = 0.013, P = 0.006), while BCAAs in red and processed meat or fish were inversely associated with low-density lipoprotein cholesterol (β = 0.025, P = 0.001) and total cholesterol (β = 0.012, P = 0.033), respectively. BCAAs in whole grains and nuts were associated with higher HDL-C (β = 0.011, P = 0.016), and lower TG (β=-0.021, P = 0.041) and diastolic blood pressure (β=-0.003, P = 0.027). Also, BCAAs from soy or vegetables and fruits were inversely associated with arterial stiffness (β=-0.018, P = 0.047) and systolic blood pressure (β=-0.011, P = 0.003), respectively. However, BCAAs in refined grains were positively associated with triglycerides (β = 0.037, P = 0.014). Total serum BCAAs were unfavorably associated with multiple cardiometabolic risk markers (all P < 0.05).
CONCLUSIONS: Dietary BCAAs in poultry, whole grains and nuts, soy, and vegetables and fruits may be favorably, while BCAAs in red and processed meat, fish, and refined grains were unfavorably associated with cardiometabolic health. Serum BCAAs showed a detrimental association with cardiometabolic risk markers.