■偏头痛患者心脑血管事件的长期风险增加。然而,这些患者是否更容易患白质病变(WMLs)仍存在争议.为了探索这个问题,我们的研究评估了偏头痛患者中RLS的比例,并探讨了右向左分流(RLS)与WMLs之间的关系.
■在这项研究中,我们纳入了998例偏头痛患者.对比经颅多普勒(c-TCD)用于诊断RLS并评估RLS患者的分流程度。在998名患者中,505接受了头颅磁共振成像(MRI)评估。WMLs分为脑室周围白质病变(pvWMLs)和深部白质病变(dWMLs)。
■在998名偏头痛患者中,946例偏头痛无先兆(MO;平均年龄36.68±10.46岁;80.5%为女性),52例有先兆偏头痛(MA;平均年龄29.85±8.59岁;71.2%为女性)。与MO患者相比,MA患者的发病年龄较早(23.1±7.97vs.28.44±10.38岁,p<0。001)和较短的疾病持续时间(6.76vs.8.34年,p=0.024)。RLS患者的总体比例为41.9%,MA组中RLS患者的比例高于MO组(55.8%vs.41.1%,p=0.037)。MO组中无/少量分流的RLS阳性患者的百分比高于MA组(81.5%vs.65.4%,p=0.004),而在MA组中,中/大分流的RLS阳性患者的百分比更高(34.6%vs.18.5%,p=0.024)。WML阳性组(n=173)的RLS患者比例低于WML阴性组(n=332),但差异不显著(40.5%与45.8%,p=0.253)。
■这项研究显示,41.9%的偏头痛患者患有RLS,RLS患者比例为41。MO组为1%,MA组为55.8%。偏头痛患者的RLS阳性率可能与WMLs的发生率无关。
UNASSIGNED: Migraine patients have an increased long-term risk of cardio and cerebrovascular events. However, whether these patients are more susceptible to white matter lesions (WMLs) remains debated. To explore this question, our study assessed the proportion of RLS in migraine patients and explored the association between right-to-left shunt (RLS) and WMLs.
UNASSIGNED: In this study, we included 998 migraine patients. Contrast transcranial doppler (c-TCD) was used to diagnose RLS and assess the extent of the shunt in RLS patients. Of the 998 patients, 505 underwent cranial magnetic resonance imaging (MRI) assessments. WMLs were classified into periventricular white matter lesions (pvWMLs) and deep white matter lesions (dWMLs).
UNASSIGNED: Among the 998 migraine patients, 946 had migraine without aura (MO; mean age 36.68 ± 10.46 years; 80.5% female), and 52 had migraine with aura (MA; mean age 29.85 ± 8.59 years; 71.2% female). Compared with MO patients, MA patients had an earlier onset age (23.1 ± 7.97 vs. 28.44 ± 10.38 years, p < 0. 001) and a shorter disease duration (6.76 vs. 8.34 years, p = 0.024). The overall proportion of RLS patients was 41.9%, with a greater proportion of RLS patients in the MA group than in the MO group (55.8% vs. 41. 1%, p = 0.037). The percentage of RLS-positive patients with no/small shunt was greater in the MO group than in the MA group (81.5% vs. 65.4%, p = 0.004), whereas the percentage of RLS-positive patients with moderate/large shunt was greater in the MA group (34.6% vs. 18.5%, p = 0.024). The proportion of RLS patients was lower in the WML-positive group (n = 173) than in the WML-negative group (n = 332), but the difference was not significant (40.5% vs. 45.8%, p = 0.253).
UNASSIGNED: This study revealed that 41.9% of migraine patients had RLS, and the proportion of RLS patients was 41. 1% in the MO group and 55.8% in the MA group. The rate of RLS positivity in migraine patients may not be related to the incidence of WMLs.