目的:本研究旨在研究过去/当前睡眠持续时间与大脑宏观/微观结构结局之间的关联,并探讨高血压或社会活动是否在这种关联中起作用。
方法:在英国生物银行内,40.436无痴呆的参与者(年龄40-70岁)接受了基线评估,然后在9年后进行了脑磁共振成像(MRI)扫描。记录过去(基线)和当前(MRI扫描)睡眠持续时间(小时/天)并分类为短(≤5),中间(6-8),和长(≥9)。通过MRI扫描评估脑结构体积和扩散标志物。
结果:与过去的中间睡眠相比,过去的短暂睡眠与较小的皮质体积(标准化β[95%CI]:-0.04[-0.07,-0.02])和较低的区域各向异性分数(FA)(-0.08[-0.13,-0.03])有关,而过去的长时间睡眠与较小的区域皮层下体积有关(丘脑的标准化β:-0.04至-0.07,伏隔,和海马)。与目前的中间睡眠相比,当前的短睡眠与较小的皮质体积相关(-0.03[-0.05,-0.01]),较大的白质高强度(WMH)体积(0.04[0.01,0.08]),和较低的区域FA(-0.07[-0.11,-0.02])。然而,当前的长睡眠与较小的总脑有关(-0.03[-0.05,-0.02]),灰质(-0.05[-0.07,-0.03]),皮质(-0.05[-0.07,-0.03]),区域皮质下体积[壳核的标准化β:-0.05至-0.09,丘脑,海马体,和伏隔]),较大的WMH体积(0.06[0.03,0.09]),以及较低的区域FA(-0.05[-0.09,-0.02])。在患有高血压或社会活动频率低的人群中,当前长睡眠时间与大脑健康不良之间的关联更强(所有P交互<0.05)。
结论:过去和现在的短/长睡眠都与较小的脑容量和较差的脑白质健康有关。特别是在高血压和社会活动频率低的个体中。我们的研究结果强调了维持6-8小时睡眠时间以保持健康的大脑衰老的必要性。
OBJECTIVE: This study aimed to examine the association between past/current sleep duration and macro-/micro-structural brain outcomes and explore whether hypertension or social activity plays a role in such association.
METHODS: Within the UK Biobank, 40 436 dementia-free participants (age 40-70 years) underwent a baseline assessment followed by a brain magnetic resonance imaging (MRI) scan 9 years later. Past (baseline) and current (MRI scans) sleep duration (hours/day) were recorded and classified as short (≤5), intermediate (6-8), and long (≥9). Brain structural volumes and diffusion markers were assessed by MRI scans.
RESULTS: Compared with past intermediate sleep, past short sleep was related to smaller cortex volumes (standardized β [95 % CI]: -0.04 [-0.07, -0.02]) and lower regional fractional anisotropy (FA) (-0.08 [-0.13, -0.03]), while past long sleep was related to smaller regional subcortical volumes (standardized β: -0.04 to -0.07 for thalamus, accumbens, and hippocampus). Compared to current intermediate sleep, current short sleep was associated with smaller cortex volumes (-0.03 [-0.05, -0.01]), greater white matter hyperintensities (WMH) volumes (0.04 [0.01, 0.08]), and lower regional FA (-0.07 [-0.11, -0.02]). However, current long sleep was related to smaller total brain (-0.03 [-0.05, -0.02]), grey matter (-0.05 [-0.07, -0.03]), cortex (-0.05 [-0.07, -0.03]), regional subcortical volumes [standardized β: -0.05 to -0.09 for putamen, thalamus, hippocampus, and accumbens]), greater WMH volumes (0.06 [0.03, 0.09]), as well as lower regional FA (-0.05 [-0.09, -0.02]). The association between current long sleep duration and poor brain health was stronger among people with hypertension or low frequency of social activity (all Pinteraction <0.05).
CONCLUSIONS: Both past and current short/long sleep are associated with smaller brain volume and poorer white matter health in the brain, especially in individuals with hypertension and low frequency of social activity. Our findings highlight the need to maintain 6-8 h\' sleep duration for healthy brain aging.