30kDa的内膜相关蛋白(IM30),也称为质体1中的囊泡诱导蛋白(Vipp1),对蓝细菌的光自养生长至关重要,藻类和高等植物。虽然它的确切功能在很大程度上仍然难以捉摸,人们普遍认为IM30与类囊体膜生物发生密切相关,稳定和/或维护。IM30的一个特征性特征是其形成大的同源寡聚蛋白质复合物的内在倾向。15年前,据报道,这些超复合物具有环状结构。然而,这些环状结构在体内的意义尚未最终解决,并且已经报道了更复杂的组装体的形成。我们在这里介绍并讨论了在过去25年中对IM30进行的研究,特别强调了为什么我们在体内可能需要IM30超复合物的问题。
The inner membrane-associated protein of 30 kDa (IM30), also known as the vesicle-inducing protein in plastids 1 (
Vipp1), is essential for photo-autotrophic growth of cyanobacteria, algae and higher plants. While its exact function still remains largely elusive, it is commonly accepted that IM30 is crucially involved in thylakoid membrane biogenesis, stabilization and/or maintenance. A characteristic feature of IM30 is its intrinsic propensity to form large homo-oligomeric protein complexes. 15 years ago, it has been reported that these supercomplexes have a ring-shaped structure. However, the in vivo significance of these ring structures is not finally resolved yet and the formation of more complex assemblies has been reported. We here present and discuss research on IM30 conducted within the past 25 years with a special emphasis on the question of why we potentially need IM30 supercomplexes in vivo.