■炎症的血液学生物标志物在临床实践中可以作为有价值的辅助手段,在鉴别诊断等几个方面提供帮助,用于患者分层和监测抗菌治疗疗效的预后评估。这项研究的目的是评估中性粒细胞与淋巴细胞比率(NLR)的疗效,血小板与淋巴细胞比率(PLR),淋巴细胞与单核细胞比率(LMR),和全身炎症指数(SII)预测细菌性性传播感染(STI)。
■这项前瞻性研究是在罗马尼亚西北部地区进行的,包括来自皮肤科等几个医疗特殊单位的患者,妇产科,泌尿科,和一般实践。研究组包括高度怀疑性传播感染的患者,对照组由健康受试者组成。定量数据以中位数(四分位数间距)表示。
■SII的中值,NLR,和SIRI在患有性传播疾病的受试者组中高于对照组[604.06(432.36-880.02)vs.556.89(388.63-874.19);2.61(1.57-3.3)与2.29(1.66-3.26);0.95(0.53-1.52)与0.89(0.67-1.34)]。关于PLR,与对照组相比,性传播疾病受试者组的中位数较低[138.1(99.19-169.6)vs.140.65(117-190.32)]。至于LMR,两组的中位数相等[4.64(3.74-6.11)与4.64(3.75-5.45)]。然而,差异未达到显著性水平。
■我们的研究表明,炎症生物标志物可能有助于检测细菌性传播感染,但其显著性未得到统计学证实。需要对替代实验室测试进行进一步研究,以改善STI的诊断和管理。
UNASSIGNED: Hematologic biomarkers of inflammation may serve as valuable adjuncts in clinical practice, aiding in several aspects such as differential diagnosis, prognostic assessment for patient stratification and monitoring the efficacy of antimicrobial therapy. The aim of this study was to evaluate the efficacy of Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), Lymphocyte to Monocyte Ratio (LMR), and Systemic Inflammatory Index (SII) in predicting bacterial sexually transmitted infections (STI).
UNASSIGNED: This prospective study was conducted in the north-west region of Romania and included patients from several medical special units such as dermatology, obstetrics-gynecology, urology, and general practice. The study group comprised patients with a high suspicion of STI, while the control group consisted of healthy subjects. Quantitative data are presented as medians (interquartile ranges).
UNASSIGNED: The median values of SII, NLR, and SIRI were higher in the group of subjects with sexually transmitted diseases compared to the control group [604.06 (432.36 - 880.02) vs. 556.89 (388.63 - 874.19); 2.61 (1.57 - 3.3) vs. 2.29 (1.66 - 3.26); and 0.95 (0.53 - 1.52) vs. 0.89 (0.67 - 1.34)]. Regarding PLR, the median values were lower in the group of subjects with sexually transmitted diseases compared to the control group [138.1 (99.19 - 169.6) vs. 140.65 (117 - 190.32)]. As for LMR, the median values were equal between the two groups [4.64 (3.74 - 6.11) vs. 4.64 (3.75 - 5.45)]. Nevertheless, the differences did not reach the significance level.
UNASSIGNED: Our study suggests that inflammatory biomarkers might aid in detecting bacterial STIs, but their significance was not statistically confirmed. Further research on alternative laboratory tests is needed for improved STI diagnosis and management.