背景:膝骨关节炎(KOA)是一种以疼痛和功能障碍为特征的慢性肌肉骨骼疾病。低负荷阻力训练(LLRT)的血流限制(BFR)在治疗KOA方面与高负荷阻力训练(HLRT)的临床结果相似。尚未确定LLRT的间歇性血流限制(iBFR)是否可以导致与LLRT和HLRT的连续血流限制(cBFR)产生的临床结果相当的临床结果。拟议研究的目的是评估iBFR与LLRT对疼痛的疗效,西安大略省和麦克马斯特大学骨关节炎指数(WOMAC),肌肉力量,肌肉质量,物理功能,对不适和努力的看法,KOA患者的依从性。
方法:这是一个三臂,非自卑,使用盲法评估的随机对照试验。两百十三名参与者将被随机分配到以下三组之一:iBFR组-接受iBFR4个月的LLRT,每周两次(n=71);cBFR组-接受4个月的LLRT与cBFR,每周两次(n=71);或接受4个月无BFR的HLRT的HLRT组,每周两次(n=71)。主要结果是疼痛。次要结果包括WOMAC,肌肉力量,肌肉质量,物理功能,对不适和努力的看法,和坚持。将在基线和随机化后4个月和12个月测量疼痛和WOMAC。肌肉力量,肌肉质量,和身体功能将在基线和随机化后4个月进行测量。不适和努力的感觉将在第一次和最后一次会议期间进行测量。
结论:BFR与LLRT在临床结局方面的改善与HLRT相似。然而,cBFR可能会导致感知到的劳累和局部不适的评级升高,损害患者的耐受性和治疗依从性。如果iBFR与LLRT可以产生类似于HLRT和iBFR与LLRT的临床结果的改善,它可以被认为是治疗KOA患者的替代方法.
背景:中国临床试验注册ChiCTR2300072820。2023年6月26日注册。
BACKGROUND: Knee osteoarthritis (KOA) is a chronic musculoskeletal disorder characterized by pain and functional impairment. Blood flow restriction (BFR) with low-load resistance training (LLRT) demonstrates a similar improvement in clinical outcomes to high-load resistance training (HLRT) in treating KOA. It has not been established whether intermittent blood flow restriction (iBFR) with LLRT can lead to clinical outcomes that are comparable to those produced by continuous blood flow restriction (cBFR) with LLRT and HLRT. The aim of the proposed study is to evaluate the efficacy of iBFR with LLRT on pain, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), muscle strength, muscle mass, physical function, perceptions of discomfort and effort, and adherence in KOA patients.
METHODS: This is a three-arm, non-inferiority, randomized controlled trial utilizing blinded assessors. Two hundred thirteen participants will be randomly allocated to one of the following three groups: iBFR group-receiving 4 months of LLRT with iBFR, twice weekly (n = 71); cBFR group-receiving 4 months of LLRT with cBFR, twice weekly (n = 71); or HLRT group-receiving 4 months of HLRT without BFR, twice weekly (n = 71). The primary outcome is pain. The secondary outcomes include the WOMAC, muscle strength, muscle mass, physical function, perceptions of discomfort and effort, and adherence. Pain and WOMAC will be measured at the baseline and 4 and 12 months after randomizations. Muscle strength, muscle mass, and physical function will be measured at the baseline and 4 months after randomizations. The perceptions of discomfort and effort will be measured during the first and final sessions.
CONCLUSIONS: BFR with LLRT has a similar improvement in clinical outcomes as HLRT. However, cBFR may cause elevated ratings of perceived exertion and local discomfort, compromising patient tolerability and treatment adherence. If iBFR with LLRT could produce improvement in clinical outcomes analogous to those of HLRT and iBFR with LLRT, it could be considered an alternative approach for treating patients with KOA.
BACKGROUND: Chinese Clinical Trial Registry ChiCTR2300072820. Registered on June 26, 2023.