■在卡拉奇反复爆发霍乱。季节性模式的变化,在这些爆发中观察到血清型和抗生素耐药性。最近,在2022年,在4月至6月期间,卡拉奇报告的霍乱病例激增。本研究旨在确定临床特征,抗生素敏感性,并发症,以及在印度河医院就诊的儿童对霍乱弧菌感染的治疗反应,卡拉奇.
■对0-16岁儿童的儿科患者进行回顾性图表回顾。包括2022年3月至6月在印度河医院接受文化证实的霍乱感染治疗的所有儿童。详细的临床特征,并发症,抗生素敏感性,从医院的健康管理信息系统(HMIS)检索对治疗的反应。
■包括20名儿童。中位年龄为01(0.50-3.75)岁。有9名(45%)男性和11名(55%)女性。所有培养分离株都属于霍乱弧菌的O1Ogawa血清群。呕吐和腹泻是最常见的症状。脱水,急性肾损伤,19例(95%)出现休克,6(30%),和2名(10%)儿童。11名儿童入院,平均住院时间为5天(中位IQR3-6天)。这些分离株对四环素完全敏感,环丙沙星,和阿奇霉素.给予不同的抗生素,包括头孢噻肟,头孢曲松,多西环素,还有环丙沙星.所有儿童对抗生素反应完全。
■在本研究中,所有霍乱弧菌分离株都属于O1Ogawa血清型,对四环素完全敏感,环丙沙星,和阿奇霉素.脱水,电解质不平衡,肾功能损害是最常见的并发症。饮用生水被认为是大多数儿童霍乱的潜在来源。因此,建议倡导卫生习惯和对供水进行消毒,以防止将来爆发霍乱。
UNASSIGNED: Repeated outbreaks of cholera have occurred in Karachi. Changing patterns in seasonality, serotypes and antibiotic resistance have been observed in these outbreaks. Recently, in the year 2022, a surge of cholera cases has been reported from Karachi during the months of April-June. This study aimed to identify clinical features, antibiotic susceptibility, complications, and response to treatment of V. cholerae infection among children attending Indus hospital, Karachi.
UNASSIGNED: A retrospective chart review of pediatric patients was conducted for children aged 0-16 years. All children treated for culture-proven cholera infection at Indus Hospital from March to June 2022 were included. Details of clinical features, complications, antibiotic susceptibility, and response to treatment were retrieved from the health management information system (HMIS) of the hospital.
UNASSIGNED: Twenty children were included. The median age was 01 (0.50-3.75) years. There were 9 (45%) males and 11 (55%) females. All the culture isolates belonged to serogroup O1 Ogawa of the Vibrio cholerae. Vomiting and diarrhea were the most common symptoms. Dehydration, acute kidney injury, and shock were seen in 19 (95%), 6 (30%), and 2 (10%) children respectively. Eleven children were admitted with an average hospital stay of 5 (Median-IQR 3-6) days. The isolates were completely susceptible to tetracycline, ciprofloxacin, and azithromycin. Different antibiotics were given which included cefotaxime, ceftriaxone, doxycycline, and ciprofloxacin. All children responded completely to the antibiotics.
UNASSIGNED: In present study all V. cholerae isolates belonged to the O1 Ogawa serotype that showed complete susceptibility to tetracycline, ciprofloxacin, and azithromycin. Dehydration, electrolyte imbalance, and renal impairment were the most common complications observed. Drinking unboiled water was identified as a potential source of cholera in most children. Therefore, advocacy of hygienic practices and disinfection of water supplies is recommended to prevent future cholera outbreaks.