■全球,约有20-25万人受到镰状细胞病(SCD)的影响,60%的患者生活在撒哈拉以南非洲。尽管最近的治疗进展导致SCD患者的预期寿命提高,尚未对SCD女性患者的高危型人乳头瘤病毒(hr-HPV)和宫颈病变的患病率进行研究.我们确定了女性SCD患者中hr-HPV和宫颈病变的患病率,并推荐了该队列中降低宫颈癌发病率的策略。
■通过mPharma10,000妇女倡议,接受过培训的护士对在加纳临床遗传学研究所SCD诊所进行常规访视的SCD女性进行筛查.通过同时进行MA-6000hr-HPVDNA测试和来自mobileODT的增强视觉评估(EVA)移动阴道镜检查进行筛选。
■在接受筛查的168名参与者中(平均年龄,43.0年),hr-HPV感染和宫颈病变的总患病率分别为28.6%(95%CI,21.7-35.4)和3.6%(95%CI,0.8-6.4),分别。按血红蛋白基因型分层的hr-HPV患病率分别为29.4%(95%CI,19.7-39.1)和28.6%(95%CI,18.5-38.7)基因型SS和SC,分别。五名SF基因型女性均未检测出hr-HPV阳性,和唯一具有Sbthal基因型的患者检测hr-HPV阳性。两名女性为EVA“阳性”,但hr-HPV阴性,而4例EVA阳性和hr-HPV阳性。探索性分析显示hr-HPV阳性与年龄之间没有显着关联,教育水平,婚姻状况或平等。
在缺乏旨在将患有SCD的妇女纳入特殊人群的全面的国家子宫颈筛查计划的情况下,SCD患者中宫颈癌的发生频率可能增加.因此,有必要为患有SCD的妇女建立能力并扩大筛查服务范围.
UNASSIGNED: Worldwide, about 20-25 million people are affected by sickle cell disease (SCD), with 60% of patients living in sub-Saharan Africa. Despite recent therapeutic advancements resulting in improved life expectancy among SCD patients, the prevalence of high-risk human papillomavirus (hr-HPV) and cervical lesions have not been studied in women with SCD. We determined the prevalence of hr-HPV and cervical lesions among women with SCD and recommended strategies for reducing cervical cancer incidence in this cohort.
UNASSIGNED: Through the mPharma 10,000 Women Initiative, women with SCD attending routine visits at the Ghana Institute of Clinical Genetics SCD clinic were screened by trained nurses. Screening was performed via concurrent MA-6000 hr-HPV DNA testing and enhanced visual assessment (EVA) mobile colposcopy from mobileODT.
UNASSIGNED: Among 168 participants screened (mean age, 43.0 years), the overall prevalence rates of hr-HPV infection and cervical lesions were 28.6% (95% CI, 21.7-35.4) and 3.6% (95% CI, 0.8-6.4), respectively. The hr-HPV prevalence rates stratified by haemoglobin genotype were 29.4% (95% CI, 19.7-39.1) and 28.6% (95% CI, 18.5-38.7) for genotypes SS and SC, respectively. None of the five women with the SF genotype tested hr-HPV positive, and the only patient with Sbthal genotype tested hr-HPV positive. Two women were EVA \'positive\' but hr-HPV negative, whereas four were EVA positive and hr-HPV positive. Exploratory analysis revealed no significant associations between hr-HPV positivity and age, education level, marital status or parity.
UNASSIGNED: In the absence of a comprehensive national cervical screening programme aimed at including women with SCD as a special population, cervical cancer may increase in frequency among SCD patients. Thus, there is a need to build capacity and expand the scope of screening services for women with SCD.