■子宫内膜异位症与卵巢癌的风险增加有关;然而,子宫内膜异位症亚型和卵巢癌组织学之间的关联尚未得到很好的描述.
■为了评估子宫内膜异位症亚型与卵巢癌发病率的关系,整体和组织型。
■基于人口的队列研究,使用来自犹他州人口数据库的数据。该队列是通过将78893名患有子宫内膜异位症的女性与没有子宫内膜异位症的女性以1:5的比例进行匹配而组成的。
■通过电子健康记录确定子宫内膜异位症病例,并将其归类为浅表子宫内膜异位症,卵巢子宫内膜瘤,深部浸润型子宫内膜异位症,或其他。
■估计的调整危险比(aHRs),每10000名女性调整后的风险差异(aRD),总体卵巢癌的CI为95%,I型卵巢癌,和II型卵巢癌比较了每种类型子宫内膜异位症的女性和没有子宫内膜异位症的女性。模型考虑了社会人口因素,生殖史,和过去的妇科手术。
■在这个基于犹他州的队列中,首次诊断子宫内膜异位症的平均年龄(SD)为36(10)岁.有597名妇女患有卵巢癌。与没有子宫内膜异位症的女性相比,患有子宫内膜异位症的女性卵巢癌风险更高(aHR,4.20[95%CI,3.59-4.91];aRD,9.90[95%CI,7.22-12.57]),I型卵巢癌的风险特别高(aHR,7.48[95%CI,5.80-9.65];aRD,7.53[95%CI,5.46-9.61])。对于所有卵巢癌,深度浸润性子宫内膜异位症和/或卵巢子宫内膜瘤的女性卵巢癌风险最高(aHR,9.66[95%CI,7.77-12.00];aRD,26.71[95%CI,20.01-33.41]),I型卵巢癌(aHR,18.96[95%CI,13.78-26.08];aRD,19.57[95%CI,13.80-25.35]),和II型卵巢癌(aHR,3.72[95%CI,2.31-5.98];aRD,2.42[95%CI,-0.01至4.85])。
患有卵巢子宫内膜异位症和/或深部浸润性子宫内膜异位症的女性卵巢癌风险显著增加。该人群可能受益于有关卵巢癌风险和预防的咨询,并且可能是靶向筛查和预防研究的重要人群。
UNASSIGNED: Endometriosis has been associated with an increased risk of ovarian cancer; however, the associations between endometriosis subtypes and ovarian cancer histotypes have not been well-described.
UNASSIGNED: To evaluate the associations of endometriosis subtypes with incidence of ovarian cancer, both overall and by histotype.
UNASSIGNED: Population-based cohort study using data from the
Utah Population Database. The cohort was assembled by matching 78 893 women with endometriosis in a 1:5 ratio to women without endometriosis.
UNASSIGNED: Endometriosis cases were identified via electronic health records and categorized as superficial endometriosis, ovarian endometriomas, deep infiltrating endometriosis, or other.
UNASSIGNED: Estimated adjusted hazard ratios (aHRs), adjusted risk differences (aRDs) per 10 000 women, and 95% CIs for overall ovarian cancer, type I ovarian cancer, and type II ovarian cancer comparing women with each type of endometriosis with women without endometriosis. Models accounted for sociodemographic factors, reproductive history, and past gynecologic operations.
UNASSIGNED: In this
Utah-based cohort, the mean (SD) age at first endometriosis diagnosis was 36 (10) years. There were 597 women with ovarian cancer. Ovarian cancer risk was higher among women with endometriosis compared with women without endometriosis (aHR, 4.20 [95% CI, 3.59-4.91]; aRD, 9.90 [95% CI, 7.22-12.57]), and risk of type I ovarian cancer was especially high (aHR, 7.48 [95% CI, 5.80-9.65]; aRD, 7.53 [95% CI, 5.46-9.61]). Ovarian cancer risk was highest in women with deep infiltrating endometriosis and/or ovarian endometriomas for all ovarian cancers (aHR, 9.66 [95% CI, 7.77-12.00]; aRD, 26.71 [95% CI, 20.01-33.41]), type I ovarian cancer (aHR, 18.96 [95% CI, 13.78-26.08]; aRD, 19.57 [95% CI, 13.80-25.35]), and type II ovarian cancer (aHR, 3.72 [95% CI, 2.31-5.98]; aRD, 2.42 [95% CI, -0.01 to 4.85]).
UNASSIGNED: Ovarian cancer risk was markedly increased among women with ovarian endometriomas and/or deep infiltrating endometriosis. This population may benefit from counseling regarding ovarian cancer risk and prevention and could be an important population for targeted screening and prevention studies.