■根治性手术对患者的健康相关生活质量(HRQoL)可能产生的负面影响在术前咨询中起着重要作用。这里,我们在单臂2期多中心研究的背景下分析了接受上尿路尿路上皮癌(UTUC)治疗的患者的HRQoL,其中研究了一次术前膀胱内滴注丝裂霉素C的安全性和有效性。我们的目的是调查接受UTUC根治性手术的患者HRQoL的早期变化,并确定与这些结果相关的因素。
■pTanyN0-1M0UTUC患者被前瞻性纳入。HRQoL使用欧洲癌症研究和治疗组织的生活质量问卷C30(EORTCQLQ-C30)问卷在基线时进行评估,手术后1个月和3个月。使用线性混合模型来评估HRQoL随时间的变化,并确定与这些结果相关的变量。临床效果大小用于评估临床医生和/或患者基于给定阈值的HRQoL变化的临床影响和感知水平。
■在2017年至2020年之间,纳入了186例患者。在基线,手术后1mo,手术后3个月,反应率为91%,84%,78%,分别。手术后一个月,在身体上观察到有统计学意义和临床相关的恶化,角色,和社会功能,以及包括的症状量表:便秘,疲劳,和痛苦。观察到情绪功能的改善。在3个月,HRQoL恢复到基线水平,除了情感功能,在1个月时有所改善,并持续优于手术前。年龄>70岁与身体功能恶化有关,而是更好的社交和情感功能。男性患者的情绪功能优于女性。术后并发症与社会功能呈负相关。
■接受根治性手术治疗的UTUC患者经历了显著的,虽然是暂时的,HRQoL下降。手术后三个月,HRQoL结果恢复至基线水平。此信息可用于在接受根治性手术之前为UTUC患者提供咨询,并在手术后进行康复。
我们调查了接受上尿路尿路上皮癌(UTUC)手术的患者的生活质量变化。我们发现患者术后1个月的生活质量下降,但这只是暂时的,术后3个月生活质量完全恢复。这些发现可以帮助医生和其他医务人员在接受根治性手术之前为UTUC患者提供咨询。
UNASSIGNED: The possible negative impact of radical surgery on patients\' health-related quality of life (HRQoL) plays an important role in preoperative counseling. Here, we analyzed the HRQoL of patients treated for upper urinary tract urothelial carcinoma (UTUC) in the context of a single-arm phase 2 multicenter study, in which the safety and efficacy of a single preoperative intravesical instillation with mitomycin C were investigated. Our objective was to investigate early changes in HRQoL in patients undergoing radical surgery for UTUC and identify factors associated with these outcomes.
UNASSIGNED: Patients with pTanyN0-1M0 UTUC were prospectively included. HRQoL was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) questionnaire at baseline, and at 1 and 3 mo after surgery. A linear mixed model was used to evaluate the changes in HRQoL over time and identify the variables associated with these outcomes. The clinical effect size was used to assess the clinical impact and level of perceptibility of HRQoL changes for clinicians and/or patients based on given thresholds.
UNASSIGNED: Between 2017 and 2020, 186 patients were included. At baseline, 1 mo after surgery, and 3 mo after surgery, response rates were 91%, 84%, and 78%, respectively. One month after surgery, a statistically significant and clinically relevant deterioration was observed in physical, role, and social functioning, and for the included symptom scales: constipation, fatigue, and pain. An improvement in emotional functioning was observed. At 3 mo, HRQoL returned to baseline levels, except emotional functioning, which improved at 1 mo and persisted to be better than that before surgery. Age >70 yr was associated with worse physical functioning, but better social and emotional functioning. Male patients reported better emotional functioning than females. Postoperative complications were negatively associated with social functioning.
UNASSIGNED: UTUC patients treated with radical surgery experienced a significant, albeit temporary, decline in HRQoL. Three months following surgery, HRQoL outcomes returned to baseline levels. This information can be used to counsel UTUC patients before undergoing radical surgery and contextualize recovery after surgery.
UNASSIGNED: We investigated the changes in quality of life as reported by patients who underwent surgery for upper tract urothelial carcinoma (UTUC). We found that patients experienced a decline in quality of life 1 mo after surgery, but this was temporary, with full recovery of quality of life 3 mo after surgery. These findings can help doctors and other medical staff in counseling UTUC patients before undergoing radical surgery.