■主动脉的机械性能在临床医学和法医学中尤为重要,作为进一步探索主动脉疾病或损伤机制的基础数据。
■为了研究各种因素的影响(年龄,性别,测试方向,解剖位置,和病理特征)对主动脉的机械性能和厚度。
■在这项研究中,共收集了24个主动脉(年龄范围:54-88岁),制作了一百七十四个狗骨形样品,然后进行单轴拉伸试验,最后,通过组织学染色进行病理分组。
■动脉粥样硬化斑块主要分布在血管分支开口附近。分布在腹主动脉最为严重,然后是主动脉弓.主动脉粥样硬化在男性组中有更严重的趋势。在厚度的比较中,年龄(超过50岁)和测试方向没有显着差异,男性组的主动脉平均厚度大于女性组,从升主动脉到腹主动脉逐渐减少。比较机械参数,各种参数主要与年龄负相关,尤其是在环状升主动脉中(εp\"Y=-0.01402*X+1.762,R2=0.6882\",εt\"Y=-0.01062*X+1.250,R2=0.6772\");健康组男性参数较大,而动脉粥样硬化组女性的参数较大;主动脉具有各向异性,圆周方向的参数大于轴向方向的参数;升主动脉的参数在圆周方向上最大,腹主动脉的极限应力[σp\"1.69(1.08,2.32)\"]和极限弹性模量[E2\"8.28(6.67,10.25)\"]在轴向上明显增大;在圆周方向,应力[σp\“2.2(1.31,3.98)\”,自适应内膜增厚的σt\"0.13(0.09,0.31)\"]和极限弹性模量(E2\"14.10±7.21\")大于其他组,应变(εp“0.82±0.17”,病理性内膜增厚的εt“0.53±0.14”)在病理组中最大。
■本研究系统分析了年龄的影响,性别,测试方向,解剖部位,以及主动脉生物力学特性的病理特征,描述了主动脉粥样硬化的分布,说明了主动脉厚度变化的特点。同时,提出了对病理特征分组的新见解。
UNASSIGNED: The mechanical properties of the aorta are particularly important in clinical medicine and forensic science, serving as basic data for further exploration of aortic disease or injury mechanisms.
UNASSIGNED: To study the influence of various factors (age, gender, test direction, anatomical location, and pathological characteristics) on the mechanical properties and thickness of the aorta.
UNASSIGNED: In this study, a total of 24 aortas (age range: 54-88 years old) were collected, one hundred and seventy-four dog-bone-shaped samples were made, and then the uniaxial tensile test was run, finally, pathological grouping was performed through histological staining.
UNASSIGNED: Atherosclerotic plaques were mainly distributed near the openings of blood vessel branches. The distribution was most severe in the abdominal aorta, followed by the aortic arch. Aortic atherosclerosis was a more severe trend in the male group. In the comparison of thickness, there were no significant differences in age (over 50 years) and test direction, the average thickness of the aorta was greater in the male group than the female group and decreased progressively from the ascending aorta to the abdominal aorta. Comparing the mechanical parameters, various parameters are mainly negatively correlated with age, especially in the circumferential ascending aorta (εp \"Y = -0.01402*X + 1.762, R2 = 0.6882\", εt \"Y = -0.01062*X + 1.250, R2 = 0.6772\"); the parameters of males in the healthy group were larger, while the parameters of females were larger in atherosclerosis group; the aorta has anisotropy, the parameters in the circumferential direction were greater than those in the axial direction; the parameters of the ascending aorta were the largest in the circumferential direction, the ultimate stress [σp \"1.69 (1.08,2.32)\"] and ultimate elastic modulus [E2\"8.28 (6.67,10.25)\"] of the abdominal aorta were significantly larger in the axial direction; In the circumferential direction, the stress [σp \"2.2 (1.31,3.98)\", σt \"0.13 (0.09,0.31)\"] and ultimate elastic modulus (E2 \"14.10 ± 7.21\") of adaptive intimal thickening were greater than those of other groups, the strain (εp \"0.82 ± 0.17\", εt \"0.53 ± 0.14\") of pathological intimal thickening was the largest in the pathological group.
UNASSIGNED: The present study systematically analyzed the influence of age, sex, test direction, anatomical site, and pathological characteristics on the biomechanical properties of the aorta, described the distribution of aortic atherosclerosis, and illustrated the characteristics of aortic thickness changes. At the same time, new insights into the grouping of pathological features were presented.