■为了评估地区5岁以下儿童的全球异物吸入负担(FBA)的变化,年龄,性别,和1990年至2019年的社会人口指数(SDI)水平。
■FBA的数据来自2019年全球疾病负担(GBD)研究数据库中的肺吸入和气道异物。计算发生率的平均值和95%不确定度区间(UI),和残疾调整寿命年(DALYs)。使用Joinpoint回归通过估计的年度百分比变化(EAPC)表示时间趋势。
■全球,2019年,FBA导致每100,000例发病率109.6(95%UI:69.5,175.7)和每100,000例5岁以下DALYs317.9(95%UI:270.7,372.4)。许多欧洲国家(如意大利、荷兰,冰岛,等。)显示出很高的发病率,但没有造成很大的疾病负担(DALY都低于每100,000人中200人)。与1990年相比,尽管2019年发病率和DALYs均有所下降,但Joinpoint回归显示2014年至2019年发病率呈上升趋势[APC:两者(2.10),女性(2.25),男性(1.98),P<0.05)],尤其是中国,荷兰,马耳他。尽管早期新生儿组和SDI中部地区的发病率较低,相反,它们导致比其他年龄组和地区更高的DALY。
■尽管从1990年到2014年,5岁以下儿童的FBA发病率和DALY下降,但从2014年到2019年开始出现上升趋势。发病率和DALY率与年龄和SDI相关。需要加大努力,改进必要的监测和报告系统,危害评估,和公共教育活动。
UNASSIGNED: To evaluate the changes in the global burden of foreign body aspiration (FBA) among children under 5 years old at regional, age, sex, and socio-demographic index (SDI) levels between 1990 and 2019.
UNASSIGNED: Data on FBA was derived from the Global Burden of Disease (GBD) Study 2019 database on pulmonary aspiration and foreign body in airway. The means and 95% uncertainty intervals (UIs) were calculated for incidence, and disability-adjusted life-years (DALYs). The temporal trends were represented by estimated annual percentage change (EAPC) using Joinpoint regression.
UNASSIGNED: Globally, FBA caused 109.6 (95% UI: 69.5, 175.7) per 100,000 incidence and 317.9 (95% UI: 270.7, 372.4) per 100,000 DALYs under 5 years old in 2019. Many European countries (such as Italy, Netherlands, Iceland, etc.) showed a high incidence rate, but did not cause a large disease burden (DALYs all less than 200 per 100,000). Compared to 1990, although a decrease in both incidence and DALYs occurred in 2019, the Joinpoint regression showed an increasing trend in incidence rate from 2014 to 2019 [APC: both (2.10), female (2.25), male (1.98), P < 0.05)], especially China, Netherlands, and Malta. Despite the lower incidence rate in early neonatal group and middle SDI areas, they instead resulted in higher DALYs than other age groups and areas.
UNASSIGNED: Although declines occurred in incidence and DALYs of FBA among children under 5 years of age from 1990 to 2014, an upward trend began to emerge from 2014 to 2019. The incidence and DALY rates were correlated with age and SDI. Increased efforts are needed to improve the necessary monitoring and reporting systems, hazard assessment, and public education activities.