目的:评价超声睫状体成形术(UCP)治疗青光眼的疗效和安全性。
方法:对PubMed的全面搜索,Embase,WebofScience,谷歌学者数据库用于选择符合纳入标准的研究。Meta分析由ReviewManager和StataCorpLLC进行。
结果:共有19篇文章符合纳入标准。总的来说,UCP在青光眼治疗中是安全有效的,成功率的风险比(RR)为2.28(95CI,1.82-2.84).在UCP之后,患者的眼内压(IOP;mmHg)显着降低,加权平均差(WMD)为11.39(95CI,9.88-12.90).此外,UCP术后并发症较少,RR为0.30(95CI,0.19-0.49)。大多数并发症是短期和轻度的。术后,患者使用降眼压药物减少,标准化平均差异(SMD)为0.78(95CI,0.40-1.17)。然而,UCP术后最佳矫正视力(BCVA;logMAR)无明显改善,WMD为0.01(95CI,-0.06-0.09)。这个程序确实减轻了痛苦,RR为3.06(95CI,1.95-4.81)。
结论:UCP对适合的青光眼有效且安全。能有效降低青光眼患者眼压,减少患者术后对降低眼压药物的依赖,减轻痛苦,减少长期或严重的术后并发症,但BCVA没有改善多少。
OBJECTIVE: To evaluate the efficacy and safety of ultrasound cycloplasty (UCP) for glaucoma.
METHODS: A comprehensive search of PubMed, Embase, Web of Science, and Google Scholar databases was used to select studies met the inclusion criteria. Meta-analysis was performed by Review Manager and StataCorp LLC.
RESULTS: A total of 19 articles met the inclusion criteria. Overall, UCP is effective and safe in the glaucoma treatment, the risk ratio (RR) of the success rate was 2.28 (95%CI, 1.82-2.84). After UCP, patients had a significant reduction in intraocular pressure (IOP; mm Hg), the weighted mean difference (WMD) was 11.39 (95%CI, 9.88-12.90). In addition, UCP brings fewer postoperative complications with RR of 0.30 (95%CI, 0.19-0.49). Most of the complications were short-term and mild. Postoperatively, patients\' use of IOP-lowering medications reduced, the standardized mean difference (SMD) was 0.78 (95%CI, 0.40-1.17). However, best corrected visual acuity (BCVA; logMAR) did not have obvious improvement after UCP, the WMD was 0.01 (95%CI, -0.06-0.09). This procedure does provide painfulness relief, with RR of 3.06 (95%CI, 1.95-4.81).
CONCLUSIONS: UCP is effective and safe for suitable glaucoma. It can effectively decrease IOP in glaucoma patients, reduce the patients\' dependence on IOP-lowering medications after surgery, relief the painfulness and has fewer long-term or severe postoperative complications, but the BCVA did not improve much.