UNASSIGNED:评估带光子计数探测器(PCD)CT的超高分辨率冠状动脉CT血管造影(CCTA)对定量冠状动脉斑块表征的影响。
未经批准:在IRB批准的研究中,20例患者的22个斑块(7名女性;平均年龄77±8岁,平均体重指数26.1±3.6kg/m2)接受心电图(ECG)门控超高分辨率CCTA和PCD-CT.用光滑(Bv40)和锋利(Bv64)的血管内核重建图像,使用量子迭代重建(强度等级4),使用0.6、0.4和0.2毫米的切片厚度,分别(视场200毫米×200毫米,矩阵大小512×512像素)。用Bv40内核和0.6mm切片厚度的重建作为参考标准。在确定血管直径≥2mm的冠状动脉斑块后,使用专门的,半自动斑块定量软件。总斑块,钙化,纤维化,和富含脂质的斑块成分在所有数据集中进行了定量。
UNASSIGNED:对于参考标准的重建,斑块体积中位数最高(23.5mm3,四分位数17.9-34.3mm3),对于切片厚度为0.2mm的超高分辨率重建,最低为Bv64内核(18.1mm3,四分位数14.1-25.8mm3,p<0.001)。参考标准的重建显示最大的钙化(85.1%,四分位数76.4-91.1%)和最小的富含脂质的斑块成分(0.5%,四分位数0.0-1.5%)。最小的钙化斑块成分(75.2%,四分位数69.9-80.8%)和最大的富含脂质的成分(6.7%,四分位数5.1-8.4%)用于切片厚度为0.2mm和Bv64内核的超高分辨率重建。在相同的切片厚度下,钙化成分的体积总是较低,与Bv40内核重建相比,Bv64内核重建的富含脂质成分的体积始终更高(所有,p<0.001)。
UNASSIGNED:这项患者研究表明PCD-CT超高分辨率扫描在定量冠状动脉斑块特征上存在显著差异。减少的模糊伪影可以允许使用PCD-CT的超高分辨率模式改善纤维化和富含脂质的斑块成分的可视化。
UNASSIGNED: To assess the effect of ultra-high-resolution coronary CT angiography (CCTA) with photon-counting detector (PCD) CT on quantitative coronary plaque characterization.
UNASSIGNED: In this IRB-approved study, 22 plaques of 20 patients (7 women; mean age 77 ± 8 years, mean body mass index 26.1 ± 3.6 kg/m2) undergoing electrocardiography (ECG)-gated ultra-high-resolution CCTA with PCD-CT were included. Images were reconstructed with a smooth (Bv40) and a sharp (Bv64) vascular kernel, with quantum iterative reconstruction (strength level 4), and using a slice thickness of 0.6, 0.4, and 0.2 mm, respectively (field-of-view 200 mm × 200 mm, matrix size 512 × 512 pixels). Reconstructions with the Bv40 kernel and slice thickness of 0.6 mm served as the reference standard. After identification of a plaque in coronary arteries with a vessel diameter ≥2 mm, plaque composition was determined using a dedicated, semi-automated plaque quantification software. Total plaque, calcified, fibrotic, and lipid-rich plaque components were quantified in all datasets.
UNASSIGNED: Median plaque volume was highest (23.5 mm3, interquartiles 17.9-34.3 mm3) for reconstructions with the reference standard and lowest for ultra-high-resolution reconstructions with a slice thickness of 0.2 mm and the Bv64 kernel (18.1 mm3, interquartiles 14.1-25.8 mm3, p < 0.001). Reconstructions with the reference standard showed largest calcified (85.1%, interquartiles 76.4-91.1%) and smallest lipid-rich plaque components (0.5%, interquartiles 0.0-1.5%). Smallest calcified plaque components (75.2%, interquartiles 69.9-80.8%) and largest lipid-rich components (6.7%, interquartiles 5.1-8.4%) were found for ultra-high-resolution reconstructions with a slice thickness of 0.2 mm and the Bv64 kernel. At an identical slice thickness, volume of calcified components was always lower, and volume of lipid-rich components was always higher for reconstructions with the Bv64 kernel compared with reconstructions with the Bv40 kernel (all, p < 0.001).
UNASSIGNED: This patient study indicates significant differences of ultra-high-resolution scanning with PCD-CT on quantitative coronary plaque characterization. Reduced blooming artifacts may allow improved visualization of fibrotic and lipid-rich plaque components with the ultra-high-resolution mode of PCD-CT.