■饮食因素与疝气之间的关系目前尚不清楚。
■英国生物库用于提取用作暴露的饮食因素,包括酒精的摄入,非油性鱼,牛肉,新鲜水果,油性鱼,沙拉/生蔬菜,干果,咖啡,麦片,盐,茶,水,煮熟的蔬菜,奶酪,羊肉/羊肉,猪肉,家禽,加工肉,和面包。FinnGen生物库用于获得关于疝气的GWAS数据作为结果。这项研究的主要分析是使用加权中位数进行的,MR-Egger,和IVW方法。Cochran的Q检验用于评估异质性。为了找到潜在的异常值,使用MR-PRESSO方法。采用留一法分析评估IVW方法的稳健性。
■每周饮酒(OR:0.614;p=0.00614)可降低腹股沟疝的风险。饮酒频率(OR:1.309;p=0.0477)增加了腹侧疝(主要包括切口疝和造口旁疝)的风险。摄入非油性鱼(OR:2.945;p=0.0214)会增加腹股沟疝的风险。添加到食物中的盐(OR:1.841;p=0.00267)会增加脐疝的风险。奶酪摄入量(OR:0.434;p=0.000536)和干果摄入量(OR:0.322;p=0.00716)降低了腹壁疝的风险,而摄入煮熟的蔬菜(OR:4.475;p=0.0380)会增加腹侧疝的风险。未发现其他饮食因素与疝气的因果关系。
■腹股沟,脐带缆,脐带缆腹侧疝都与饮食因素有关。
UNASSIGNED: The relationship between dietary factors and hernias is currently unclear.
UNASSIGNED: The UK Biobank was used to extract dietary factors that were used as exposures, including intake of alcohol, non-oily fish, beef, fresh fruit, oily fish, salad/raw vegetables, dried fruit, coffee, cereal, salt, tea, water, cooked vegetables, cheese, Lamb/mutton, pork, poultry, processed meat, and bread. The FinnGen biobank was used to obtain GWAS data on hernias as outcomes. The main analysis of this study was performed using the weighted median, MR-Egger, and IVW methods. Cochran\'s Q test was utilized to assess heterogeneity. To find potential outliers, the MR-PRESSO method was used. Leave-one-out analysis was employed to assess the IVW method\'s robustness.
UNASSIGNED: Alcoholic consumption per week (OR: 0.614; p = 0.00614) reduced the risk of inguinal hernia. Alcohol intake frequency (OR: 1.309; p = 0.0477) increased the risk of ventral hernia (mainly including incisional hernia and parastomal hernia). The intake of non-oily fish (OR: 2.945; p = 0.0214) increased the risk of inguinal hernia. Salt added to food (OR: 1.841; p = 0.00267) increased the risk of umbilical hernia. Cheese intake (OR: 0.434; p = 0.000536) and dried fruit intake (OR: 0.322; p = 0.00716) decreased the risk of ventral hernia, while cooked vegetable intake (OR: 4.475; p = 0.0380) increased the risk of ventral hernia. No causal relationships were found with hernias from other dietary factors.
UNASSIGNED: Inguinal, umbilical, and ventral hernias are all related to dietary factors.