Tenascin-C是一个很大的,多模块,细胞外基质糖蛋白,表现出非常有限的表达模式,但功能却千差万别。这里,我们讨论了破译表达模式的重要性,以及由以下因素介导的影响,这种分子的不同形式,以便充分理解生腱蛋白-C生物学。我们专注于转录后和翻译后事件,如剪接,糖基化,组装成3D基质和蛋白水解切割,强调这些修改是如何定义tenascin-C函数的关键。
Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and effects mediated by, different forms of this molecule in order to fully understand tenascin-C biology. We focus on both post transcriptional and post translational events such as splicing, glycosylation, assembly into a 3D matrix and proteolytic cleavage, highlighting how these modifications are key to defining tenascin-C function.