■膳食大豆蛋白(SP)是保护肾脏和改善葡萄糖和脂质代谢的潜在干预措施。然而,这种影响是否与SP摄入百分比有关尚不清楚.
■本研究旨在回顾和分析接受不同SP百分比饮食的2型糖尿病肾病(T2DN)患者的随机临床试验(RCT)的结果。
■数据库:PubMed,Embase,Cochrane中央对照试验登记册(中央),WebofScience,中国国家知识基础设施(CNKI),中国生物医学文献数据库(CBM),万方,维普(VIP),直到2023年2月,在T2DN和SP上搜索了ClinicalTrials.gov。
■共纳入六项研究,包括116名参与者。干预措施被分类为0%SP,35%SP,100%SP为了改善血清肌酐(Scr),血尿素氮(BUN),24小时尿总蛋白(24hUTP),和肾小球滤过率(GFR),35%的SP饮食是最有效的,与0%SP饮食相比,24hUTP的平均差为-154.00(95%置信区间:-266.69,-41.31)。虽然它对24hUTP有显著的好处,观察到很大的异质性。为了改善糖脂代谢相关标志物,如胆固醇(CHO),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C),空腹血糖(FPG),和体重,与0%SP饮食相比,35%SP饮食显示出更好的疗效。具体来说,CHO的平均差为-0.55(95%置信区间:-1.08,-0.03),对于LDL-C,它是-17.71(95%置信区间:-39.67,-4.24)。其他指标无统计学意义。大多数研究都担心偏见的风险。
■这项研究的结果表明,在改善T2DN患者的肾功能和糖脂代谢方面,35%和100%SP饮食都比无SP饮食更有效。因此,含35%SP的饮食可能是T2DN患者的最佳选择.
■https://www.crd.约克。AC.uk/PROSPERO/display_record。php?RecordID=352638,标识符CRD42022352638。
UNASSIGNED: Dietary soy protein (SP) is a potential intervention for protecting the kidneys and improving glucose and lipid metabolism. However, whether this effect is related to the percentage of SP intake remains unclear.
UNASSIGNED: This study aims to review and analyze the results of randomized clinical trials (RCTs) in patients with type 2 diabetic nephropathy (T2DN) who received diets with different percentages of SP.
UNASSIGNED: The databases: PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, China National Knowledge Infrastructure (CNKI), Chinese BioMedical Literature Database (CBM), WanFang, Weipu (VIP), and ClinicalTrials.gov were searched until February 2023, for RCTs on T2DN and SP.
UNASSIGNED: A total of six studies comprising 116 participants were included. The interventions were classified as 0% SP, 35% SP, and 100% SP. To improve serum creatinine (Scr), blood urea nitrogen (BUN), 24-h urine total protein (24hUTP), and glomerular filtration rate (GFR), a 35% SP diet was the most effective, compared to a 0% SP diet, which showed a mean difference of -154.00 (95% confidence interval: -266.69, -41.31) for 24hUTP. Although it had significant benefits for 24hUTP, great heterogeneity was observed. To improve the glycolipid metabolism-related markers such as cholesterol (CHO), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FPG), and weight, the 35% SP diet demonstrated superior efficacy compared to the 0% SP diet. Specifically, the mean difference for CHO was -0.55 (95% confidence interval: -1.08, -0.03), and for LDL-C, it was -17.71 (95% confidence interval: -39.67, -4.24). The other indicators were not statistically significant. Most studies had concerns regarding the risk of bias.
UNASSIGNED: The findings of this study demonstrate that both 35% and 100% SP diets are more effective than a diet with no SP in improving renal function and glucolipid metabolism in patients with T2DN. As a result, a diet incorporating 35% SP may be the optimal choice for individuals with T2DN.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=352638, identifier CRD42022352638.