锥虫是单细胞原生动物,在撒哈拉以南非洲国家的人类和牲畜中引起严重疾病。由于锥虫耐受性的问题,西非矮羊(WAD)的疾病通常被忽略。目前的研究旨在评估该品种的一些生化变化,这些变化可能会改变对锥虫耐受性的理解。将15只WAD绵羊分为3组(A,B,andC).在A组和B组感染布氏锥虫和刚果锥虫之前,获得所测定参数的基线(第0天)值,分别,通过每只动物腹膜内接种106锥虫。使用QuimicaClinicaApplicada(西班牙)和Randox(英国)检测试剂盒的标准程序用于评估AST的血清水平,ALT,ALP,总蛋白质,白蛋白,总胆固醇,尿素,感染后第0、14、28、42、56和70天的肌酐。感染导致持续发热,低蛋白血症,低胆固醇血症,减肥,肝炎,尽管寄生虫血症得到了很大控制,但死亡率得到了很大控制,尤其是在T感染的公羊中。研究结果表明,WAD公羊不仅仅是锥虫在人类和动物感染中的被动储库,但是经历活跃的宿主-寄生虫相互作用却付出了巨大的弹性代价,生物化学。
Trypanosomes are single-celled protozoa that cause severe diseases in both humans and livestock in sub-Saharan African countries. The disease in the West African Dwarf (WAD) sheep is often neglected due to the issue of
trypanotolerance. The current study is aimed to evaluate some biochemical changes in this breed that may modify the understanding of
trypanotolerance. Fifteen WAD sheep were assigned into 3 groups (A, B, and C). Baseline (day 0) values of the parameters assayed were obtained before groups A and B were infected with Trypanosoma brucei brucei and Trypanosoma congolense, respectively, by intraperitoneal inoculation with 106 trypanosomes per animal. Standard procedures using Quimica Clinica Applicada (Spain) and Randox (UK) test kits were used to evaluate serum levels of AST, ALT, ALP, total protein, albumin, total cholesterol, urea, and creatinine on days 0, 14, 28, 42, 56, and 70 post infection. The infections caused sustained pyrexia, hypoproteinaemia, hypocholesterolaemia, weight loss, hepatitis, and mortalities although parasitaemia was greatly controlled especially in the T congolense infected rams. The findings suggest that the WAD rams are not just passive reservoirs of trypanosomes for human and animal infections, but experience active host-parasite interactions with huge price for resilience, biochemically.