背景:Triatoma感染,巴西三甲,三叶草和杜氏是克鲁氏锥虫的载体,查加斯病的病因。鸡是三叶草的重要血液食物来源。这项研究旨在评估对鸡施用的fluralaner(Exzolt®)对三叶草的杀虫活性(R。prolixus,T.昆虫,巴西产草业和假草业)。
方法:根据体重将十二只非品种鸡(家鸡)随机分为三组:阴性对照(n=4);单剂量0.5mg/kg氟尿嘧啶(Exzolt®)(n=4);两个剂量0.5mg/kg氟尿嘧啶(Exzolt®)(n=4)。第三的若虫,四龄和五龄R.prolixus,T.昆虫,在处理之前,允许T.brasiliensis和T.pseumaculata(所有n=10)以鸡为饲料,治疗后1、7、14、21、28、35和56天,昆虫死亡率确定。
结果:用两种剂量的fluralaner处理显示出较高的杀虫效果。与单剂量治疗相比。对于一个剂量和两个剂量的fluralaner,假花青虫观察到类似的杀虫功效。在用一剂量和两剂量的fluralaner治疗后21天和28天,注意到fluralaner(Exzolt®)对triatomine虫的杀虫活性,分别。
结论:结果表明,用fluralaner(Exzolt®)处理鸡在处理后长达28天的时间内可诱导对三叶草的杀虫活性,提示其在流行地区作为恰加斯病控制策略的潜在用途。
BACKGROUND: Triatoma infestans, Triatoma brasiliensis, Triatoma pseudomaculata and Rhodnius prolixus are vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Chickens serve as an important blood food source for triatomines. This study aimed to assess the insecticidal activity of fluralaner (Exzolt®) administered to chickens against triatomines (R. prolixus, T. infestans, T. brasiliensis and T. pseudomaculata).
METHODS: Twelve non-breed chickens (Gallus gallus domesticus) were randomized based on weight into three groups: negative control (n = 4); a single dose of 0.5 mg/kg fluralaner (Exzolt®) (n = 4); two doses of 0.5 mg/kg fluralaner (Exzolt®) (n = 4). Nymphs of 3rd, 4th and 5th instars of R. prolixus, T. infestans, T. brasiliensis and T. pseudomaculata (all n = 10) were allowed to feed on chickens before treatment, and at intervals of 1, 7, 14, 21, 28, 35 and 56 days after treatment, with insect mortality determined.
RESULTS: Treatment with two doses of fluralaner showed higher insecticidal efficacy against R. prolixus, T. infestans and T. brasiliensis compared to the single-dose treatment. Similar insecticidal efficacy was observed for T. pseudomaculata for one and two doses of fluralaner. Insecticidal activity of fluralaner (Exzolt®) against triatomine bugs was noted up to 21 and 28 days after treatment with one and two doses of fluralaner, respectively.
CONCLUSIONS: The results demonstrate that treatment of chickens with fluralaner (Exzolt®) induces insecticidal activity against triatomines for up to 28 days post-treatment, suggesting its potential use as a control strategy for Chagas disease in endemic areas.