背景:在普通人群中缺乏三叶因子(TFF)与胃癌和癌前病变(PML)的相关性研究是TFF在胃癌筛查中应用的重要障碍。我们旨在分析一般人群中TFF与胃癌和PML的相关性。
方法:我们评估了居住在武威的3986名成年人,中国。我们收集了基线特征和胃癌危险因素,包括TFF,内镜诊断,和病理信息。建立三个logistic回归模型分析TFF与胃癌的关系,以及PML。计算调整后的比值比(OR)和95%置信区间(95%CI)以确定关联强度。
结果:与胃蛋白酶原(PG)和抗幽门螺杆菌免疫球蛋白G抗体(Hp-IgG)相比,校正生物标志物和危险因素后,TFF与胃癌和PMLs有显著相关性(P<0.05)。TFF1的OR(95%CI)(1.67;1.27-2.20),TFF2(2.66;2.01-3.51),和TFF3(1.32;1.00-1.74)大于PGI的OR(0.79;0.61-1.03),PGI/II(1.00;0.76-1.31),胃癌组Hp-IgG(0.99;0.73-1.35)。在肠上皮化生(IM)组中,不仅TFF3血清水平最高,而且OR(1.92;1.64-2.25)最高。
结论:TFF与胃癌和PML的风险相关。
结论:血清TFF可以提高胃癌高危人群的筛查。
BACKGROUND: A lack of research on the association of trefoil factors (TFF) with gastric cancer and premalignant lesions (PML) in the general population is an important obstacle to the application of TFFs for gastric cancer screening. We aimed to analyze the association of TFFs with gastric cancer and PMLs in a general population.
METHODS: We evaluated 3,986 adults residing in Wuwei, China. We collected baseline characteristics and gastric cancer risk factors, including TFFs, endoscopic diagnosis, and pathologic information. Three logistic regression models were generated to analyze the association between TFFs and gastric cancer, as well as PMLs. Adjusted odds ratio (OR) and 95% confidence intervals (95% CI) were calculated to determine the strength of association.
RESULTS: Compared with pepsinogen (PG) and anti-Helicobacter pylori immunoglobulin G antibody (Hp-IgG), TFFs had significant association with gastric cancer and PMLs after adjusting for biomarkers and risk factors (P < 0.05). The ORs (95% CI) for TFF1 (1.67; 1.27-2.20), TFF2 (2.66; 2.01-3.51), and TFF3 (1.32; 1.00-1.74) were larger than the ORs for PGI (0.79; 0.61-1.03), PGI/II (1.00; 0.76-1.31), and Hp-IgG (0.99; 0.73-1.35) in the gastric cancer group. In the intestinal metaplasia (IM) group, not only the TFF3 serum level was the highest, but also the OR (1.92; 1.64-2.25) was the highest.
CONCLUSIONS: TFFs were associated with risk of gastric cancer and PMLs.
CONCLUSIONS: Serum TFFs can improve the screening of high-risk populations for gastric cancer.