目的:乳腺癌在65岁及以上的女性中很常见。由于临床研究中很少包括这些患者,因此该年龄段患者的乳腺癌治疗缺乏证据。然而,众所周知,未接受标准治疗的老年乳腺癌患者的生存率显着降低。几个因素,包括患者合并症,性能状态,预期寿命,和肿瘤的病理和分子特征,会影响治疗的结果。在这项研究中,我们旨在通过在多中心数据集中的老年人群中评估这些因素来更新该领域的知识.
方法:这项回顾性研究分析了335名65岁及以上的乳腺癌患者的数据,这些患者在五个肿瘤中心接受了辅助放疗(Kartal博士LutfiKirdar培训和研究医院,伊斯坦布尔,梅兰医学院-NecmettinErbakan大学,Konya,Prof.CemilTascioglu市医院,伊斯坦布尔,Umraniye培训和研究医院,伊斯坦布尔,伊斯坦布尔肿瘤医院,伊斯坦布尔)在2010年5月至2022年9月之间。人口统计,临床,并收集病理资料,包括年龄,性别,临床症状,肿瘤特征,治疗方法,和结果。统计分析,包括描述性统计,Kaplan-Meier分析,对数秩检验,和Cox回归分析,使用IBMSPSSStatisticsforWindows执行,版本22(2013年发布;IBMCorp.,Armonk,纽约,美国),显著性水平为p<0.05。
结果:对335例乳腺癌患者的肿瘤特征和生存时间进行分析。在结果中,性能状态,T级,神经周浸润是影响老年乳腺癌患者生存的因素。在多变量分析中,可以看出,表现状况作为独立的预后因素发挥了重要作用.
结论:老年年龄组乳腺癌的治疗需要个性化的方法,考虑到患者的整体健康状况,预期寿命,和合并症。
OBJECTIVE: Breast cancer is common among women aged 65 and over. There is a significant lack of evidence regarding the treatment of breast cancer in patients in this age group due to the rare inclusion of these patients in clinical studies. However, it is known that survival in elderly patients with breast cancer is significantly reduced in those not receiving standard therapy. Several factors, including patients\' comorbidities, performance status, life expectancy, and tumor pathological and molecular characteristics, can affect the outcomes of treatment. In this study, we aimed to update the knowledge in this field by assessing these factors among the geriatric population in our multicenter dataset.
METHODS: This retrospective study analyzed data from 335 breast cancer patients aged 65 and over who received adjuvant radiotherapy at five oncology centers (Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Meram Medical Faculty - Necmettin Erbakan University, Konya, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Umraniye Training and Research Hospital, Istanbul, and Istanbul Oncology Hospital, Istanbul) between May 2010 and September 2022. Demographic, clinical, and pathological data were collected, including age, gender, clinical symptoms, tumor characteristics, treatment approaches, and outcomes. Statistical analyses, including descriptive statistics, Kaplan-Meier analysis, log-rank test, and Cox regression analysis, were performed using IBM SPSS Statistics for Windows, Version 22 (Released 2013; IBM Corp., Armonk, New York, United States), with a significance level of p < 0.05.
RESULTS: The tumor characteristics and survival time of 335 breast cancer patients were examined. In the results, performance status, T stage, and perineural invasion were found to be factors affecting the survival of elderly breast cancer patients. In multivariate analysis, it was seen that performance status played an important role as an independent prognostic factor.
CONCLUSIONS: The treatment of breast cancer in the geriatric age group necessitates a personalized approach, taking into account the patient\'s overall health status, life expectancy, and comorbidities.