基于导丝的压力测量对于诊断冠状动脉疾病至关重要。然而,导丝对局部血流动力学和诊断结果的影响尚不完全清楚.在这项研究中,我们提出了一个广义的降阶模型(ROM)来准确预测动脉中的跨狭窄压降。该模型的一个关键优点是粘性项不依赖于经验参数,使其适用于有和没有导丝插入的情况,以及不同的狭窄严重程度。与3D理想化数值模型相比,该模型具有良好的准确性,在没有导丝的情况下,平均预测误差为3.61%,在有导丝的情况下,平均预测误差为4.53%。此外,当应用于特定于患者的模型时,与以前发布的ROM相比,它实现了可比或更好的结果。最后,该ROM用于研究在各种狭窄严重程度下跨狭窄压降的不同成分的相对重要性的变化,并进一步了解导丝对FFR测量的影响。
Guidewire-based pressure measurement is essential for diagnosing coronary artery disease. However, the impact of the guidewire on local hemodynamics and diagnostic outcomes is not fully understood. In this study, we propose a generalized reduced-order model (ROM) to accurately predict the trans-stenotic pressure drop in arteries. A key advantage of this model is that the viscous term does not rely on empirical parameters, making it applicable to both scenarios with and without guidewire insertion, and across varying stenosis severities. The proposed model demonstrates good accuracy compared to 3D idealized numerical models, achieving an average prediction error of 3.61% for cases without a guidewire and 4.53% for cases with a guidewire. Furthermore, when applied to a patient-specific model, it achieves comparable or better results than previously published ROMs. Finally, this ROM is employed to investigate the shifting relative importance of different components of the trans-stenotic pressure drop at various stenosis severities, and to provide further insights into the guidewire\'s influence on FFR measurements.