Trans jugular intrahepatic portosystemic shunt

  • 文章类型: Case Reports
    在过去的几十年里,放射学干预在慢性肝病患者的治疗中起着至关重要的作用。各种手术,包括经交瓜肝内门体分流术(TIPS),经颈静脉肝活检(TJLB),经动脉化疗(TACE)/经动脉放射栓塞(TARE),球囊逆行经静脉闭塞术(BRTO)和塞式辅助逆行经静脉闭塞术(PARTO)安全实施,这些患者的临床结局得到显著改善.技术和临床成功取决于适当的患者选择以及全面的知识和经验来执行这些程序。另一方面,少数不良事件也可能与这些手术相关.介入放射科医师和肝病医师应尽早识别和治疗这些并发症,以改善患者的预后。
    从2022年1月至2023年5月在我们中心进行了约25例肝介入放射学程序。在这些患者中,我们选择了五名在我们研究所接受TACE/TIPS/DIPS的患者。我们选择了这些病例,因为在这些病例中,我们都遇到了一些有趣的结果/并发症,这些结果/并发症得到了成功的管理。
    第一个病例描述了33岁的男性,患有POEM综合征和BuddChiari综合征(BCS),他接受了TIPS并立即阻断了支架。第二例是一名43岁男性患有BCS,难治性腹水伴脐疝和腹股沟疝。第三例是一名40岁的失代偿期肝硬化女性,因门脉高压性胃病接受TIPS治疗。第四例是一名51岁女性,患有失代偿性肝硬化伴肌肉减少症。最后,第五例描述24岁女性患有BCS和肝细胞癌。在本文中,我们讨论了手术后患者的手术程序和临床过程。
    肝脏放射学干预虽然广泛使用,但可能与不寻常但危及生命的并发症有关。适当的患者选择和全面的程序知识以及这些并发症的早期诊断和管理是获得令人满意的长期结果的关键。
    UNASSIGNED: During last few decades, radiological interventions have played crucial role in the management of the patients with chronic liver diseases. Various procedures including transjugualar intrahepatic portosystemic shunt (TIPS), transjugular liver biopsy (TJLB), transarterial chemoembilization (TACE)/transarterial radioembolization (TARE), balloon retrograde transvenous obliteration (BRTO) and plug-assisted retrograde transvenous obliteration (PARTO) are being performed safely and have significantly improved clinical outcomes in these patients. The technical and clinical success depend on appropriate patient selection along with thorough knowledge and experience to perform these procedures. On the other hand, few adverse events may also be associated with these procedures. The intervention radiologist and hepatologists should identify and treat these complications at the earliest so as to improve outcome of the patient.
    UNASSIGNED: About 25 hepatic intervention radiology procedures were performed in our center from January 2022 to 2023 May. Among these we have selected five patients who underwent TACE/TIPS/DIPS in our institute. We have selected these cases as in each of these cases we encountered some interesting outcomes/complications which were managed successfully.
    UNASSIGNED: The first case describes 33-year-old male with POEM syndrome and Budd Chiari Syndrome (BCS) who underwent TIPS and immediately had blockade of the stent. The second case is of a 43 years old male having BCS, refractory ascites with umbilical and inguinal hernia. The third case is of a 40 years old female with decompensated cirrhosis who underwent TIPS for portal hypertensive gastropathy. The fourth case is of a 51-years\' female with decompensated cirrhosis with sarcopenia. Finally, the fifth case describes 24-year-old female with BCS and hepatocellular carcinoma. In this article we discuss the procedure and clinical course of the patients following the procedure.
    UNASSIGNED: Hepatic radiological interventions though widely used can be associated with unusual albeit life threatening complications. Appropriate patient selection and thorough knowledge of procedure along with early diagnosis and management of these complications are key to obtain satisfying long term outcomes.
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  • 文章类型: Journal Article
    静脉曲张出血是肝硬化的重要并发症,它的存在反映了肝脏疾病的严重程度。胃静脉曲张,虽然不如食管静脉曲张常见,由于其更高的出血强度和相关的死亡率,提出了一个独特的临床挑战。根据Sarin分类,GOV1是临床实践中最常见的胃静脉曲张亚型。
    Variceal bleed represents an important complication of cirrhosis, with its presence reflecting the severity of liver disease. Gastric varices, though less frequently seen than esophageal varices, present a distinct clinical challenge due to its higher intensity of bleeding and associated mortality. Based upon the Sarin classification, GOV1 is the most common subtype of gastric varices seen in clinical practice.
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  • 文章类型: Journal Article
    BACKGROUND: Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it is imperative to study interventions which targets to improve sarcopenia in cirrhosis.
    OBJECTIVE: To examine the relationship between interventions such nutritional supplementation, exercise, combined life style intervention, testosterone replacement and trans jugular intrahepatic portosystemic shunt (TIPS) to improve muscle mass in cirrhosis.
    METHODS: We search PubMed, EMBASE and Cochrane between June-August 2018, without a limiting period and the types of articles (RCTs, clinical trial, comparative study) in adult patients with sarcopenia and cirrhosis. The primary outcome of interest was improvement in muscle mass, strength and physical function interventions mentioned above. In the screening process, 154 full text articles were included in the review and 129 studies were excluded.
    RESULTS: We identified 24 studies that met review inclusion criteria. The studies were diverse in terms of the design, setting, interventions, and outcome measurements. We performed only qualitative synthesis of evidence due to heterogeneity amongst studies. Risk of bias was medium in most of the included studies and low quality of evidence showed improvement in the muscle mass, strength and physical function following aerobic exercise. 60% of the included studies on the nutritional intervention, 100% of the studies on testosterone replacement in hypogonadal men and trans-jugular portosystemic shunt were proved to be effective in improving sarcopenia in cirrhosis.
    CONCLUSIONS: Although the quality of evidence is low, the findings of our systematic review suggest improvement in the sarcopenia in cirrhosis with exercise, nutritional interventions, hormonal and TIPS interventions. High quality randomized controlled trials needed to further strengthen these findings.
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