口腔炎偶尔多发,经常性,和耐火材料。目前,癌症患者化疗和放疗引起的粘膜炎已成为一个重要的临床问题。尚未建立有效的治疗方法,许多病例的治疗仍然是医生的挑战。传统的日本草药称为Kampo配方(即,Hangeshashinto,Orengedokuto,Inchinkoto,Orento,Byakkokaninininto,Juzentaihoto,Hochuekkito,和Shosaikoto)用于治疗各种类型的口腔炎和粘膜炎。它的使用是基于Kampo医学理论-数千年来建立的经验规则。然而,最近,已经进行了研究这些配方的临床和基础研究,以获得科学证据。研究Shosaikoto和Orento治疗隐源性口炎和急性口疮性口炎的疗效的临床研究,以及研究Hangeshashinto的作用的临床研究,Orengedokuto,和Juzentaihoto对化疗或放疗引起的粘膜炎进行了研究。Kampo配方包括几种生药,其作用机制正在逐步澄清。这些用于治疗口腔炎的药物大多数具有抗炎作用,镇痛药,和抗氧化性能。在这次审查中,我们介绍了临床应用,并总结了Kampo方治疗口腔炎和口腔黏膜炎的现有证据。
Stomatitis is occasionally multiple, recurrent, and refractory. Currently, mucositis induced by chemotherapy and radiation therapy in patients with cancer has become a significant clinical problem. Effective treatments have not been established and the treatment of numerous cases remains a challenge for physicians. Traditional Japanese herbal medicines termed Kampo formulae (i.e., Hangeshashinto, Orengedokuto, Inchinkoto, Orento, Byakkokaninjinto, Juzentaihoto, Hochuekkito, and Shosaikoto) are used for treating various types of stomatitis and mucositis. Its use has been based on the Kampo medical theories-empirical rules established over thousands of years. However, recently, clinical and basic research studies investigating these formulae have been conducted to obtain scientific evidence. Clinical studies investigating efficacies of Shosaikoto and Orento for the treatment of cryptogenic stomatitis and acute aphthous stomatitis and those investigating the effects of Hangeshashinto, Orengedokuto, and Juzentaihoto on chemotherapy- or radiotherapy-induced mucositis have been conducted. The Kampo formulae comprise several crude drugs, whose mechanisms of action are gradually being clarified. Most of these drugs that are used for the treatment of stomatitis possess anti-inflammatory, analgesic, and antioxidative properties. In this review, we introduce the clinical applications and summarize the available evidence on the Kampo formulae for the treatment of stomatitis and oral mucositis.