这项研究比较了两种不同剂量的异丙酚静脉给药的效果(IV),在颈静脉,红耳滑块(Trachemysscriptaelegans)。在这项交叉研究中,颈静脉插管后,将5或10mg/kg的丙泊酚施用于六个Trachemysscriptaelegans。每只乌龟都接受了每一剂量,G1(5mg/kgIV)和G2(10mg/kgIV),经过7天的冲洗期。评估的参数是心率,睑反射,泄殖腔反射,肌肉放松,易于处理,对前部和后部挤压刺激的敏感性,和插管的可能性。此外,在可能的情况下测量呼吸频率,记录异丙酚给药到完全恢复和插管到拔管的时间。G1中的海龟都不能插管,这种剂量几乎没有放松和易于处理,该组的作用持续时间为12.16±8.32(SD)min,直至完全恢复。在G2,六只海龟中的五只可以插管,作用时间为32.33±5.85(SD)min。心率受导管放置操作的影响。两组肌松程度差异有统计学意义(p值≤0.05),处理,泄殖腔反射,和插管的可能性。5mg/kg的丙泊酚剂量不足以诱导麻醉,即使在颈静脉给药,在红耳滑块中。应使用10mg/kgIV或更高的剂量。
This study compares the effects of two different doses of propofol administered intravenously (IV), in the jugular vein, to red-eared sliders (Trachemys scripta elegans). In this crossover study, 5 or 10 mg/kg propofol was administered to six Trachemys scripta elegans after cannulation of the jugular vein. Each turtle received each dose, G1 (5 mg/kg IV) and G2 (10 mg/kg IV), after a 7-day washout period. The parameters evaluated were heart rate, palpebral reflex, cloacal reflex, muscle relaxation, ease of handling, sensitivity to anterior and posterior pinch stimuli, and possibility of intubation. Additionally, respiratory rate was measured when possible, and the times from propofol administration to full recovery and from intubation to extubation were recorded. None of the turtles in G1 could be intubated, and this dose provided little relaxation and ease of handling, with a duration of effect until full recovery of 12.16 ± 8.32 (SD) min for this group. In G2, five out of the six turtles could be intubated, and the duration of effect was 32.33 ± 5.85 (SD) min. Heart rates were influenced by manipulation for catheter placement. There were statistically significant differences (p value ≤ 0.05) between the two groups in muscle relaxation degree, handling, cloacal reflex, and possibility of intubation. The 5 mg/kg propofol dose was not sufficient to induce anesthesia, even when administered in the jugular vein, in red-eared sliders. A dose of 10 mg/kg IV or higher should be used.