■帕金森病(PD)患者表现出社会认知缺陷,特别是在心理理论(ToM)能力方面。目前尚不清楚它们是否与PD相关的多巴胺缺乏相关,并由左旋多巴替代疗法调节。
■共有15名PD患者和13名健康对照(HC)参与了研究。他们执行不同的神经心理任务,包括假发识别测试(FPRT),评估认知ToM的不同维度(例如,检测,不适当,意图),和阅读心灵中的眼睛测试(RMET)作为情感ToM的指标。PD患者接受了两次测试,一次在常规治疗下,另一次在左旋多巴戒断至少18小时后(MED-ON和MED-OFF,分别)。无论哪种情况,测量血清药物水平和运动症状严重程度[统一帕金森病评定量表(UPDRS)]。
■PD患者的MED-ON和MED-OFF状况通过前者的血清药物水平高于后者状态以及相应的运动缺陷改善得到证实。这样做,在任何与ToM相关的任务中,没有发现左旋多巴治疗的功能差异.一般来说,患者在情感和认知ToM测试中的表现均比对照组差。
■PD患者在认知和情感ToM方面存在缺陷。多巴胺替代,有效改善电机状况,似乎并不能抵消这些功能障碍。
UNASSIGNED: Patients with Parkinson\'s disease (PD) exhibit deficits in social cognition, particularly with respect to Theory of Mind (
ToM) capacities. It is unclear whether they are associated with PD-related dopamine deficiency and modulated by levodopa replacement therapy.
UNASSIGNED: A total of 15 persons with PD and 13 healthy controls (HC) participated in the study. They performed different neuropsychological tasks, including the Faux Pas Recognition Test (FPRT), assessing different dimensions of cognitive
ToM (e.g., detection, inappropriateness, intentions), and the Reading the Mind in the Eyes Test (RMET) as an index of affective
ToM. Persons with PD were tested twice, once under their regular treatment and another time after at least 18 h of levodopa withdrawal (MED-ON and MED-OFF, respectively). On either occasion, serum drug levels and motor symptom severity [Unified Parkinson\'s Disease Rating Scale (UPDRS)] were measured.
UNASSIGNED: MED-ON and MED-OFF conditions in patients with PD were confirmed by higher serum drug levels in the former than in the latter state and a corresponding amelioration of the motor deficit. In so doing, no performance difference in any ToM-related task was identified as a function of the levodopa therapy. Generally, patients performed worse than controls in both affective and cognitive
ToM tests.
UNASSIGNED: Patients with PD have deficits in cognitive and affective
ToM. Dopamine replacement, effective for improving the motor condition, does not appear to counteract these dysfunctions.