背景:终末期肾病(ESRD)是慢性肾病(CKD)的最后阶段。
目的:我们旨在分析血清血栓调节蛋白(TM)的表达差异,血小板活化因子(PAF),和P-选择素(CD62P)在自体动静脉瘘(AVF)患者中的表达及与血管通路功能的相关性。
方法:对病例资料进行回顾性分析。此外,选择160例AVF维持性血液透析患者作为AVF组,选择150例健康受试者作为健康对照组。根据血管通路的功能,将AVF组患者分为A组(n=50,在首次建立AVF后),B组(n=64,血液透析治疗后血管通路功能正常),和C组(n=46,血管通路衰竭)。进行Pearson分析以探讨血清TM,PAF,CD62P含量,和血管病理检查指标,为了评估TM的价值,PAF,和CD62P水平在预测AVF患者血管通路衰竭中的作用。
结论:血清TM水平,PAF,CD62P分别与CD68和MCP-1的表达呈正相关(p<.001)。血清TM与PAF、CD62P水平呈正相关(p<.001),PAF与CD62P水平呈正相关(p<.001),分别。血清TM水平,PAF和CD62P是AVF患者血管通路衰竭的危险因素(p<0.05)。血清TM曲线下面积,预测AVF患者血管通路衰竭的PAF和CD62P水平为0.879。
结论:血清TM水平,PAF,AVF患者的CD62P与AVF患者的血管通路功能相关,这对于维持血管通路功能的稳定性非常重要,对预测AVF患者血管通路衰竭/障碍有一定的价值,可以推广应用。
BACKGROUND: End-stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD).
OBJECTIVE: We aimed to analyze the expression differences of serum thrombomodulin (TM), platelet-activating factor (PAF), and P-selectin (CD62P) in patients with autologous arteriovenous fistula (AVF) and the correlation with vascular access function.
METHODS: The case data were retrospectively analyzed. Moreover, 160 patients with AVF maintenance hemodialysis were selected as the AVF group, and 150 healthy participants were selected as the healthy control group. According to the function of vascular access, patients in the AVF group were divided into Group A (n = 50, after the first establishment of AVF), Group B (n = 64, normal vascular access function after hemodialysis treatment), and Group C (n = 46, vascular access failure). Pearson analysis was conducted to explore the correlation between serum TM, PAF, CD62P content, and vascular pathological examination indicators, to evaluate the value of
TM, PAF, and CD62P levels in predicting vascular access failure in patients with AVF.
CONCLUSIONS: The serum levels of TM, PAF, and CD62P were positively correlated with the expressions of CD68 and MCP-1, respectively (p < .001). Serum
TM was positively correlated with the levels of PAF and CD62P (p < .001), and PAF was positively correlated with the levels of CD62P (p < .001), respectively. Serum levels of
TM, PAF and CD62P were risk factors for vascular access failure in AVF patients (p < .05). The area under the curve of serum
TM, PAF and CD62P levels in predicting vascular access failure in AVF patients was 0.879.
CONCLUSIONS: The serum levels of
TM, PAF, and CD62P in AVF patients were correlated with the vascular access function of AVF patients, which was very important for maintaining the stability of vascular access function, and had certain value in predicting vascular access failure/disorder in AVF patients, and could be popularized and applied.