背景和研究目的关于胰腺囊性病变(PCL)患者的内镜引导组织采集(EUS-TA)的有用性的数据很少。本研究旨在确定EUS-TA与ProCore20G(PC20)的准确性,以区分粘液性瘤(MN)和非MNs(n-MN)和识别恶性PCLs。以及未通过影像学检查进行分类诊断的PCL患者的不良事件(AE)。患者和方法在这个观察中,回顾性,单中心研究,我们从2017年6月至2021年12月连续招募了所有因影像学研究诊断怀疑而接受EUS-TA的PCL患者.结果是确定EUS-TA与PC20的诊断准确性,以区分MN和n-MN,识别恶性PCLs,和AE。此处的结果,145名患者接受了EUS-TA,83名女性(57.2%),平均年龄62.2岁。平均尺寸为2.3厘米,81例患者(77.9%)PCL<3.0cm。最终诊断为EUS-TA(n=81),手术(n=58),和随访(n=6)。敏感性,特异性,阳性和阴性预测值,区分MNs和n-MNs以及识别恶性PCLs的准确率为92.6%,98.4%,98.7%,91.3%,和95.2%(κ=0.9),92%,99.2%,95.8%,98.3%,和97.9%(κ=0.93),分别。AE率为2.7%,在这个队列中没有死亡。结论EUS-TA联合PC20诊断PCL具有较高的准确性和技术成功率,且AE率低。
Background and study aims There are rare data on the usefulness of endosonography-guided tissue acquisition (EUS-TA) in patients with pancreatic cystic lesions (PCLs). This study aimed to determine the accuracy of EUS-TA with ProCore 20G (PC20) for differentiating between mucinous neoplasia (MN) and non-MNs (n-MN) and identifying malignant PCLs, as well as its adverse events (AEs) in patients with PCLs without a classificatory diagnosis by imaging exams. Patients and methods In this observational, retrospective, single-center study, all patients with PCL who underwent EUS-TA due to diagnostic doubts in imaging studies were consecutively recruited from June 2017 to December 2021. The outcomes were to determine the diagnostic accuracy of EUS-TA with PC20 for differentiating between MN and n-MN, identifying malignant PCLs, and the AEs. Results Herein, 145 patients underwent EUS-TA, with 83 women (57.2%) and a mean age of 62.2 years. The mean size was 2.3 cm, with 81 patients (77.9%) having a PCL < 3.0 cm. The final diagnosis was made by EUS-TA (n = 81), surgery (n = 58), and follow-up (n = 6). The sensitivity, specificity, positive and negative predictive values, and accuracy for differentiating between MNs and n-MNs and identifying malignant PCLs were 92.6%, 98.4%, 98.7%, 91.3%, and 95.2% (kappa=0.9), and 92%, 99.2%, 95.8%, 98.3%, and 97.9% (kappa = 0.93), respectively. The AE rate was 2.7%, with no deaths in this cohort. Conclusions EUS-TA with PC20 has high accuracy and technical success with a low AE rate for PCL diagnosis.