胸腺通过充当增殖和分化淋巴细胞的仓库,在细胞免疫中起着至关重要的作用。胸腺基质细胞教育T细胞从非自身抗原中分化出自我,而护士细胞和胸腺蛋白酶体在T细胞的成熟和分化中起主要作用。胸腺条件要求T细胞应对癌症发展的风险。一项研究旨在证明无法消除肿瘤和免疫监视受损的潜在机制,以及胸腺消退延迟对癌症和自身免疫性疾病的影响。来自Pubmed的科学文献;Scopus;WOS;JSTOR;国家医学图书馆,贝塞斯达,马里兰;纽约医学院;言语康复图书馆,NY;St.Thomas\'医院图书馆;TheWillsLibraryofGuysHospital;RepositoryofKingsCollegeLondon;andOxfordAcademicRepositorywereexpectedforpathological,生理,胸腺的免疫学和毒理学研究。研究表明,全身化疗可能导致胸腺内的微炎症环境,在那里常规和动态转移的休眠细胞寻求庇护。胸腺和有缺陷的T和Treg细胞的功能失调,绕过否定选择,有助于自身免疫性疾病,而AIRE和Fezf2在胸腺上皮细胞固着中起重要作用。不同的维生素,TCM,活细胞疗法是有效的治疗方法。维生素A,C,D,E,硒和锌,华蟾素和膳食多糖,腺体提取物和活细胞注射具有恢复免疫系统功能和胸腺健康的强大潜力。此外,不同年龄/阶段的胸腺与其相应的T细胞介导的抗肿瘤免疫反应之间的关系需要进一步探索。
Thymus plays a crucial role in cellular immunity by acting as a warehouse for proliferating and differentiating lymphocytes. Thymic stromal cells educate T-cells to differentiate self from non-self antigens while nurse cells and thymoproteasome play a major role in the maturation and differentiation of T-cells. The thymic conditions dictate T-cells to cope with the risk of cancer development. A study was designed to demonstrate potential mechanisms behind the failure to eliminate tumors and impaired immune surveillance as well as the impact of delay in thymus regression on cancer and autoimmune disorders. Scientific literature from Pubmed; Scopus; WOS; JSTOR; National Library of Medicine Bethesda, Maryland; The New York Academy of Medicine; Library of Speech Rehabilitation, NY; St. Thomas\' Hospital Library; The Wills Library of Guys Hospital; Repository of Kings College London; and Oxford Academic repository was explored for pathological, physiological, immunological and toxicological studies of thymus. Studies have shown that systemic chemotherapy may lead to micro inflammatory environment within thymus where conventionally and dynamically metastasized dormant cells seek refuge. The malfunctioning of the thymus and defective T and Treg cells, bypassing negative selection, contributes to autoimmune disorders, while AIRE and Fezf2 play significant roles in thymic epithelial cell solidity. Different vitamins, TCM, and live cell therapy are effective therapeutics. Vitamin A, C, D, and E, selenium and zinc, cinobufagin and dietary polysaccharides, and glandular extracts and live cell injections have strong potential to restore immune system function and thymus health. Moreover, the relationship between different ages/stages of thymus and their corresponding T-cell mediated anti-tumor immune response needs further exploration.