背景:Parsonage-Turner综合征(PTS)的特征是严重的,急性上肢疼痛和随后的轻瘫,最常见的是长胸神经(LTN)。虽然MR神经成像(MRN)可以检测到LTN沙漏样收缩(HGC),定量肌肉MRI(qMRI)可以量化前锯齿肌(SAM)的神经源性改变。
目的:1)表征LTN参与PTS的qMRI表现。2)研究qMRI与HGC/肌电图(EMG)临床评估之间的关联。
方法:前瞻性。
方法:30名PTS受试者(25M/5F,平均/范围年龄=39/15-67岁),患有LTN,接受了双侧胸壁qMRI和单侧臂丛MRN。
■3.0特斯拉/多回波自旋回波T2映射,扩散加权回波平面成像,多回波梯度回波。
结果:进行qMRI以获得T2,肌肉直径脂肪分数(FF),和SAM的横截面积。获得了MRN和EMG的临床报告;从MRN,HGC的数量;来自EMG,SAM测量电机单元招募水平,纤颤,和积极的尖锐的波浪。在EMG的90天内进行qMRI/MRN。EMG在症状发作后平均185天(症状发作后≥2周)和MRI前5天进行。
方法:使用配对t检验比较受影响的SAM与对侧的qMRI测量值,未受影响的一侧(P<0.05认为有统计学意义)。Kendall的tau用于确定qMRI对HGC和EMG之间的关联。
结果:相对于未受影响的SAM,受影响的SAM增加了T2(50.42±6.62vs.39.09±4.23毫秒)和FF(8.45±9.69vs.4.03%±1.97%),和肌肉直径减小(74.26±21.54vs.88.73±17.61μm)和横截面积(9.21±3.75vs.16.77±6.40mm2)。个体qMRI生物标志物与HGC和EMG的临床评估之间存在微弱到可忽略的关联(tau=-0.229至<0.001,P=0.054-1.00)。
结论:在涉及LTN的PTS受试者中观察到SAM的qMRI变化。
方法:2技术效果:第一阶段。
BACKGROUND: Parsonage-Turner syndrome (PTS) is characterized by severe, acute upper extremity pain and subsequent paresis and most commonly involves the long thoracic nerve (LTN). While MR neurography (MRN) can detect LTN hourglass-like constrictions (HGCs), quantitative muscle MRI (qMRI) can quantify serratus anterior muscle (SAM) neurogenic changes.
OBJECTIVE: 1) To characterize qMRI findings in LTN-involved PTS. 2) To investigate associations between qMRI and clinical assessments of HGCs/electromyography (EMG).
METHODS: Prospective.
METHODS: 30 PTS subjects (25 M/5 F, mean/range age = 39/15-67 years) with LTN involvement who underwent bilateral chest wall qMRI and unilateral brachial plexus MRN.
UNASSIGNED: 3.0 Tesla/multiecho spin-echo T2-mapping, diffusion-weighted echo-planar-imaging, multiecho gradient echo.
RESULTS: qMRI was performed to obtain T2, muscle diameter fat fraction (FF), and cross-sectional area of the SAM. Clinical reports of MRN and EMG were obtained; from MRN, the number of HGCs; from EMG, SAM measurements of motor unit recruitment levels, fibrillations, and positive sharp waves. qMRI/MRN were performed within 90 days of EMG. EMG was performed on average 185 days from symptom onset (all ≥2 weeks from symptom onset) and 5 days preceding MRI.
METHODS: Paired t-tests were used to compare qMRI measures in the affected SAM versus the contralateral, unaffected side (P < 0.05 deemed statistically significant). Kendall\'s tau was used to determine associations between qMRI against HGCs and EMG.
RESULTS: Relative to the unaffected SAM, the affected SAM had increased T2 (50.42 ± 6.62 vs. 39.09 ± 4.23 msec) and FF (8.45 ± 9.69 vs. 4.03% ± 1.97%), and decreased muscle diameter (74.26 ± 21.54 vs. 88.73 ± 17.61 μm) and cross-sectional area (9.21 ± 3.75 vs. 16.77 ± 6.40 mm2). There were weak to negligible associations (tau = -0.229 to <0.001, P = 0.054-1.00) between individual qMRI biomarkers and clinical assessments of HGCs and EMG.
CONCLUSIONS: qMRI changes in the SAM were observed in subjects with PTS involving the LTN.
METHODS: 2 TECHNICAL EFFICACY: Stage 1.