心脏地带病毒(HRTV),一种新出现的蜱传致病性布尼亚病毒,自2012年以来一直是一个令人担忧的问题,随着发病率的增加,扩大地理分布,和高致病性在美国。HRTV感染导致发烧,血小板减少症,人类的白细胞减少症,在某些情况下,症状可以发展到严重的结果,包括出血性疾病,多器官衰竭,甚至死亡。目前,目前尚无疫苗或抗病毒药物可用于治疗HRTV疾病.此外,对HRTV与主持人的互动知之甚少,病毒复制机制,发病机制和毒力,进一步阻碍疫苗和抗病毒干预的发展。这里,我们的目的是对HRTV流行病学进行简要回顾,分子生物学,文章数据为更好地了解该病毒的致病机理和毒力,为进一步研究提供线索。
Heartland virus (HRTV), an emerging tick-borne pathogenic bunyavirus, has been a concern since 2012, with an increasing incidence, expanding geographical distribution, and high pathogenicity in the United States. Infection from HRTV results in fever, thrombocytopenia, and leucopenia in humans, and in some cases, symptoms can progress to severe outcomes, including haemorrhagic disease, multi-organ failure, and even death. Currently, no vaccines or antiviral drugs are available for treatment of the HRTV disease. Moreover, little is known about HRTV-host interactions, viral replication mechanisms, pathogenesis and virulence, further hampering the development of vaccines and antiviral interventions. Here, we aimed to provide a brief review of HRTV epidemiology, molecular biology, pathogenesis and virulence on the basis of published article data to better understand this virus and provide clues for further study.