■水杨酸甲酯,冬青油的主要化合物,广泛用于局部应用。然而,其血管和热感效应尚未完全了解。主要目的是研究局部水杨酸钠对皮肤温度(Tskin)的影响,与安慰剂凝胶相比,皮肤微循环(MCskin)和肌氧饱和度(SmO2)。次要目的是评估热感觉反应(热感觉,热舒适),并探索这些感觉在多大程度上对应于随着时间的推移的生理反应。
■21名健康女性(22.2±2.9岁)参加了这次单盲,随机对照试验。定制天然冬青油(12.9%),含有水杨酸甲酯(>99%)和安慰剂凝胶,每个1g,同时应用于两个椎旁皮肤区域(5厘米×10厘米,Th4-Th7)。Tskin(红外热成像),MCskin(激光散斑对比成像)和SmO2(深层组织氧合监测)和热感觉(李克特量表)在基线(BL)和在应用后45分钟(T0-T45)期间以5分钟的间隔进行评估。
■两种凝胶均导致Tskin的初始减少,在Tskin(min)的T5下,水杨酸甲酯(BL-T5:Δ-3.36°C)和安慰剂(BL-T5:Δ-3.90°C),随后逐渐增加(p<.001)。在T5和T40之间,水杨甲酯凝胶导致Tskin显著高于安慰剂(p<.05)。对于水杨酸甲酯,MCskin增加,MCskin(max)在T5(BL-T5:Δ88.7%)。对于安慰剂,MCskin下降(BL-T5:Δ-17.5%),在T0和T45之间与水杨酸甲酯相比具有显著较低的值(p<.05)。两种凝胶对SmO2具有最小的影响,在水杨酸钠和安慰剂之间没有显著差异(p>.05)。对局部水杨酸钠的热感觉反应范围从“凉”到“热”,在T5时报告了更强烈的感觉。
■研究结果表明,局部用水杨酸钠可诱导短期皮肤血管舒张,但它可能不会增强骨骼肌血流量。这项研究强调了其应用的复杂感官反应,这可能是基于热敏瞬时受体电位通道的短期调制。
UNASSIGNED: Methyl salicylate, the main compound of wintergreen oil, is widely used in topical applications. However, its vascular and thermosensory effects are not fully understood. The primary aim was to investigate the effects of topical methyl salicylate on skin temperature (Tskin), skin microcirculation (MCskin) and muscle oxygen saturation (SmO2) compared to a placebo gel. The secondary aim was to assess thermosensory responses (thermal sensation, thermal comfort) and to explore to which extent these sensations correspond to the physiological responses over time.
UNASSIGNED: 21 healthy women (22.2 ± 2.9 years) participated in this single-blind, randomized controlled trial. Custom-made natural wintergreen oil (12.9%), containing methyl salicylate (>99%) and a placebo gel, 1 g each, were applied simultaneously to two paravertebral skin areas (5 cm × 10 cm, Th4-Th7). Tskin (infrared thermal imaging), MCskin (laser speckle contrast imaging) and SmO2 (deep tissue oxygenation monitoring) and thermosensation (Likert scales) were assessed at baseline (BL) and at 5-min intervals during a 45 min post-application period (T0-T45).
UNASSIGNED: Both gels caused an initial decrease in Tskin, with Tskin(min) at T5 for both methyl salicylate (BL-T5: Δ-3.36°C) and placebo (BL-T5: Δ-3.90°C), followed by a gradual increase (p < .001). Methyl salicylate gel resulted in significantly higher Tskin than placebo between T5 and T40 (p < .05). For methyl salicylate, MCskin increased, with MCskin(max) at T5 (BL-T5: Δ88.7%). For placebo, MCskin decreased (BL-T5: Δ-17.5%), with significantly lower values compared to methyl salicylate between T0 and T45 (p < .05). Both gels had minimal effects on SmO2, with no significant differences between methyl salicylate and placebo (p > .05). Thermal sensation responses to topical methyl salicylate ranged from \"cool\" to \"hot\", with more intense sensations reported at T5.
UNASSIGNED: The findings indicate that topical methyl salicylate induces short-term cutaneous vasodilation, but it may not enhance skeletal muscle blood flow. This study highlights the complex sensory responses to its application, which may be based on the short-term modulation of thermosensitive transient receptor potential channels.