背景:糖尿病性白内障术后干眼综合征(DES)可严重影响患者的生活质量。因此,有效缓解本病患者的症状具有重要的临床意义。
目的:探讨重组人表皮生长因子(rhEGF)联合透明质酸钠(SH)滴眼液对糖尿病患者白内障术后DES的临床疗效。
方法:我们对天津北辰医院82例糖尿病患者进行了回顾性评估,南开大学附属医院2021年4月至2023年4月。将他们分为观察组(42例,rhEGF+SH滴眼液)和对照组(40例,单独使用SH眼药水),根据不同的治疗方案。治疗效果,干眼症状评分,泪膜破裂时间(TFBUT),基本泪液分泌评分[使用SchirmerI测试(SIt)评估],角膜荧光素染色(FL)评分,泪液炎症标记物,治疗过程中的不良反应,比较两组患者的治疗满意度。
结果:观察组疗效优于对照组。两组均表现出改善的TFBUT和干眼症,以及改善治疗后的SIt和FL评分,观察组的改善更为明显。虽然两组间不良反应无明显差异,观察组患者的治疗满意度较高。
结论:rhEGF+SH滴眼液可有效改善干眼症和视力损害,具有良好的疗效,不良反应少,和高安全水平。因此,这种治疗应在临床实践中推广。
BACKGROUND: Dry eye syndrome (DES) after diabetic cataract surgery can seriously affect the patient\'s quality of life. Therefore, effective alleviation of symptoms in patients with this disease has important clinical significance.
OBJECTIVE: To explore the clinical effect of recombinant human epidermal growth factor (rhEGF) plus sodium hyaluronate (SH) eye drops on DES after cataract surgery in patients with diabetes.
METHODS: We retrospectively evaluated 82 patients with diabetes who experienced DES after cataract surgery at Tianjin Beichen Hospital, Affiliated Hospital of Nankai University between April 2021 and April 2023. They were classified into an observation group (42 cases, rhEGF + SH eye drops) and a control group (40 cases, SH eye drops alone), depending on the different treatment schemes. The thera-peutic efficacy, dry eye symptom score, tear film breakup time (TFBUT), basic tear secretion score [assessed using Schirmer I test (SIt)], corneal fluorescein staining (FL) score, tear inflammatory markers, adverse reactions during treatment, and treatment satisfaction were compared between the two groups.
RESULTS: Therapeutic efficacy was higher in the observation group compared with the control group. Both groups showed improved TFBUT and dry eye, as well as improved SIt and FL scores after treatment, with a more pronounced improvement in the observation group. Although no marked differences in adverse reactions were observed between the two groups, treatment satisfaction was higher in the observation group.
CONCLUSIONS: rhEGF + SH eye drops rendered clinical benefits to patients by effectively ameliorating dry eye and visual impairment with favorable efficacy, fewer adverse reactions, and high safety levels. Thus, this treatment should be promoted in clinical practice.