简介:Tanacetum属由160种公认的开花物种组成,在整个温带地区蓬勃发展,主要在地中海盆地,北美,以及亚洲西南部和东部。Tanacetum物种在世界各地的土著部落和社区的民间医学中有着长期的使用记录,随着传统美食的众多应用,药妆,和农业领域。方法:与传统用途相关的最新数据,植物化学,生物活动,从几个在线科学引擎系统审查了Tanacetum属的毒性和临床试验,包括PubMed,WebofScience,Scopus,SciFinder,Wiley在线,科学直接,科克伦图书馆结果和讨论:在过去的三十年中,从近20个物种中分离出241种代谢物,包括酚酸,黄酮类化合物,香豆素,脂肪酸和烷烃,醛类,挥发性化合物,和萘醌.还发现了一些独特的代谢物,例如来自T.artemisioides的神经酰胺坦乙酰胺(A-D),除虫菊酯,和来自几个物种的倍半萜内酯。然而,这些次生代谢物的研究仍然很少,尽管在体外的线索突出了他们巨大的药理特性,尤其是低血压,神经保护,抗癌,和抗菌剂。科学研究已经验证了该植物的一些传统主张,如抗糖尿病药,抗癌,驱虫药,杀虫剂,抗氧化剂,和肝保护活动,以及对抗溃烂的伤口,皮肤溃疡,尿路感染,和性传播疾病。关节炎的其他种族医学用途,痛风,风湿病,贫血,作为一种岩溶剂,抗蛇毒血清和发汗药尚未得到支持,将构成进一步研究的主题。
Introduction: The
Tanacetum genus consists of 160 accepted flowering species thriving throughout temperate regions, mainly in the Mediterranean Basin, Northern America, and southwestern and eastern Asia.
Tanacetum species bear a long-standing record of use in the folk medicine of indigenous tribes and communities worldwide, along with multitudinous applications in traditional cuisines, cosmeceuticals, and agricultural fields. Methods: Up-to-date data related to traditional uses, phytochemistry, biological activities, toxicity and clinical trials of the genus
Tanacetum were systematically reviewed from several online scientific engines, including PubMed, Web of Science, Scopus, SciFinder, Wiley Online, Science Direct, and Cochrane library. Results and discussion: Over the past three decades, 241 metabolites have been isolated from nearly twenty species, including phenolic acids, flavonoids, coumarins, fatty acids and alkanes, aldehydes, volatile compounds, and naphthoquinones. Some unique metabolites have also been identified, such as the ceramides tanacetamide (A-D) from T. artemisioides, pyrethrins from T. cinerariifolium, and sesquiterpene lactones from several species. However, these secondary metabolites are still poorly studied despite in vitro clues highlighting their colossal pharmacological properties, especially as hypotensive, neuroprotective, anticancer, and antimicrobial agents. Scientific studies have validated some traditional claims of the plant, such as antidiabetic, anticancer, anthelmintic, insecticide, antioxidant, and hepatoprotective activities, as well as against festering wounds, skin ulcers, urinary tract infections, and sexually transmitted diseases. Other ethnomedicinal uses for arthritis, gout, rheumatism, anemia, and as a litholytic, antivenom and diaphoretic have not yet been supported and would constitute the subject of further research.