Introduction.TORCH感染的血清学筛查和血清阳性率数据是评估免疫和疫苗接种水平以及预防和治疗TORCH先天性感染的暴露率的关键工具。假说。血清学使我们能够识别易受原发感染的女性。瞄准.评估巴勒莫地区有TORCH病原体原发感染风险的妇女的患病率,西西里,意大利,在2012-2022年的十年中。方法论。进行了一项回顾性研究,以评估2359名育龄妇女(WCBA)的血清学状态(IgG和/或IgM),从16岁到46岁,参加AOUP\'PGiaccone\'巴勒莫大学医院。结果。结果显示疱疹病毒(HSV)抗TORCHIgG的总体患病率为90.5%,风疹病毒(RV)占81.2%,巨细胞病毒(CMV)占72.1%,弓形虫(TOX)为20.9%,梅毒螺旋体(TP)为4.8%。HSV2的IgM阳性率为16.9%,TOX为10.3%,4%的CMV和,2%为RV。在28.3%的血清反应阳性的妇女中,证实了TP的近期/活动性感染。我们的结果表明,只有一小部分WCBA接受了全面的TORCH血清学筛选,而大多数WCBA仅测试了一种病原体。此外,不同年龄组TORCHIgG总血清阳性率差异无统计学意义(P>0.05)。结论。确定WCBA在怀孕期间暴露的风险使我们能够预防和减少可能的先天性感染,提供详细的指南和说明。这项研究的结果表明,在意大利,通过TORCH剂获得原发性感染的风险仍然很高,因此,有效的预防策略,包括血清学筛查,应该执行。
Introduction. Serological screening and seroprevalence data for
TORCH infections represent a key instrument to estimate immunity and vaccination levels and exposure rates to prevent and treat
TORCH congenital infections.Hypothesis. Serology allows us to identify women susceptible to primary infection.Aim. Assess the prevalence of women at risk of primary infections by
TORCH pathogens in Palermo, Sicily, Italy, in the decade 2012-2022.Methodology. A retrospective study was performed to evaluate the serological status (IgG and/or IgM) of 2359 women of childbearing age (WCBA), ranging from 16 to 46 years, attending the AOUP \'P. Giaccone\' University Hospital of Palermo.Results. The results showed an overall prevalence of anti-
TORCH IgG of 90.5 % for herpesvirus (HSV), 81.2 % for rubella virus (RV), 72.1 % for cytomegalovirus (CMV), 20.9 % for Toxoplasma gondii (TOX) and 4.8 % for Treponema pallidum (TP). IgM positivity was 16.9 % for HSV2, 10.3 % for TOX, 4 % for CMV and, 2 % for RV. A recent/active infection by TP was confirmed in 28.3 % of the seropositive women. Our results indicate that only a small percentage of WCBA were subjected to a comprehensive TORCH serological screening, while most WCBA were only tested for a single pathogen. In addition, no significant differences were found in terms of the overall
TORCH IgG seroprevalence among different age groups (P>0.05).Conclusion. Identifying WCBA at risk of exposure during pregnancy allows us to prevent and reduce possible congenital infections, providing detailed guidelines and instructions. The results of this study showed that in Italy the risk of acquiring a primary infection by a TORCH agent is still high, therefore effective prevention strategies, including serological screening, should be implemented.