最近,钛酸盐纳米管(TNTs)已受到越来越多的关注,并成为在多个学科中使用的有吸引力的候选人。凭借其可喜的成绩和出色的表现,它们为使用它们的任何领域带来附加值,比如绿色化学,工程,和医学。它们良好的生物相容性,高电阻,和特殊的物理化学性质也提供了广泛的优势,这些优势对不同平台的投资至关重要,尤其是医疗和制药。水热处理是最流行的TNT制备方法之一,成本效益高,和环境友好的水基程序。由于其高产率和所得纳米管的特殊性质,它也被认为是用于生物医学应用的大规模生产的强大候选者。尤其是它们的小直径,更适合给药和长循环。根据制备条件的不同,TNTs的性质差异很大,这将影响其后续应用领域。这篇综述的目的是讨论可能影响其合成的因素,并根据因素的变化确定可能发生的转化。为了实现这一目标,相关科学数据库(WebofScience,Scopus,PubMed,等。)使用关键词钛酸盐纳米管进行搜索,水热处理,合成,温度,时间,碱性介质,后处理,酸洗,煅烧,制药应用,药物输送,等。选择了讨论通过水热合成制备TNTs的文章,讨论其他制备方法的论文被排除在外;然后,在仔细阅读所选文章的基础上对结果进行评估.对不同参数的调查和全面审查可能是关于建立TNT生产的可生产方法的几个问题的答案,它也可能有助于优化它们的特性,然后将它们的应用限制扩展到尚未完全揭示的其他领域,尤其是制药工业和药物输送。
Recently, titanate nanotubes (
TNTs) have been receiving more attention and becoming an attractive candidate for use in several disciplines. With their promising results and outstanding performance, they bring added value to any field using them, such as green chemistry, engineering, and medicine. Their good biocompatibility, high resistance, and special physicochemical properties also provide a wide spectrum of advantages that could be of crucial importance for investment in different platforms, especially medical and pharmaceutical ones. Hydrothermal treatment is one of the most popular methods for TNT preparation because it is a simple, cost-effective, and environmentally friendly water-based procedure. It is also considered as a strong candidate for large-scale production intended for biomedical application because of its high yield and the special properties of the resulting nanotubes, especially their small diameters, which are more appropriate for drug delivery and long circulation.
TNTs\' properties highly differ according to the preparation conditions, which would later affect their subsequent application field. The aim of this review is to discuss the factors that could possibly affect their synthesis and determine the transformations that could happen according to the variation of factors. To fulfil this aim, relevant scientific databases (Web of Science, Scopus, PubMed, etc.) were searched using the keywords titanate nanotubes, hydrothermal treatment, synthesis, temperature, time, alkaline medium, post treatment, acid washing, calcination, pharmaceutical applications, drug delivery, etc. The articles discussing
TNTs preparation by hydrothermal synthesis were selected, and papers discussing other preparation methods were excluded; then, the results were evaluated based on a careful reading of the selected articles. This investigation and comprehensive review of different parameters could be the answer to several problems concerning establishing a producible method of
TNTs production, and it might also help to optimize their characteristics and then extend their application limits to further domains that are not yet totally revealed, especially the pharmaceutical industry and drug delivery.