■我们研究的目的是调查TNFAIP3,PTPN22和TRAF1-5单核苷酸多态性(SNP)是否与易感性相关,严重程度,或原发性干燥综合征(pSS)的血清学标志物。
■病例和对照研究在2021年12月至2022年6月之间进行。TNFAIP3rs10499194C/T,rs6920220G/A,和rs2230926T/G,PTPN22rs2476601C/T和rs33996649G/A,使用TaqMan®SNP基因分型试验,对154名女性pSS患者(平均年龄:45.2±6.8岁)和313名女性对照受试者(平均年龄:50.3±7.5岁)的TRAF1-C5rs10818488G/A多态性进行基因分型。TNFAIP3,PTPN22和TRAF1-C5SNP与易感性之间的关联分析,临床特征,并进行了pSS的血清学标记。TNFAIP3,PTPN22和TRAF1-C5SNP之间的相互作用也在患者和对照组中进行了评估。
■基因型和等位基因频率与易感性无关,严重程度,或pSS的血清学标记。然而,TNFAIP3和TRAF1-C5或TNFAIP3,PTPN22和TRAF1-C5基因型之间的几种相互作用与pSS的易感性相关(p<0.01)。
■单个TNFAIP3、PTPN22和TRAF1-C5SNP与易感性无关,严重程度,或pSS的血清学标记。然而,TRAF1-C5和TNFAIP3或TNFAIP3,PTPN22和TRAF1-C5SNP之间的遗传相互作用是pSS的危险因素.
UNASSIGNED: The aim of our study was to investigate whether
TNFAIP3, PTPN22, and TRAF1-5 single nucleotide polymorphisms (SNPs) are associated with susceptibility, severity, or serological markers in primary Sjögren\'s syndrome (pSS).
UNASSIGNED: The cases and controls study was conducted between December 2021 and June 2022.
TNFAIP3 rs10499194C/T, rs6920220G/A, and rs2230926T/G, PTPN22 rs2476601C/T and rs33996649G/A, and TRAF1-C5 rs10818488G/A polymorphisms were genotyped in 154 female pSS patients (mean age: 45.2±6.8 years) and 313 female control subjects (mean age: 50.3±7.5 years) using the TaqMan® SNP genotyping assay. An association analysis between TNFAIP3, PTPN22, and TRAF1-C5 SNPs and susceptibility, clinical characteristics, and serological markers of pSS was performed. Interactions between
TNFAIP3, PTPN22, and TRAF1-C5 SNPs were also evaluated in patients and controls.
UNASSIGNED: The genotype and allele frequencies showed no association with susceptibility, severity, or serological markers of pSS. Nevertheless, several interactions between
TNFAIP3 and TRAF1-C5 or
TNFAIP3, PTPN22, and TRAF1-C5 genotypes were associated with susceptibility to pSS (p<0.01).
UNASSIGNED: Individual TNFAIP3, PTPN22, and TRAF1-C5 SNPs are not associated with susceptibility, severity, or serological markers of pSS. However, genetic interactions between TRAF1-C5 and
TNFAIP3 or
TNFAIP3, PTPN22, and TRAF1-C5 SNPs are risk factors for pSS.