■我们报告了粒细胞集落刺激因子注射引起的短暂性颈动脉血管周围炎症的罕见不良事件。认识到这种综合征对医生来说很重要,为了避免暴露致病药物,排除鉴别诊断,并延迟使用糖皮质激素,因为在停止致病药物后自发改善。
■一名73岁的白人妇女出现食痛症,carotidynia,在骨髓增生异常综合征的情况下,注射粒细胞集落刺激因子(G-CSF)治疗化疗引起的中性粒细胞减少症后5天发热。检查显示颈部疼痛肿胀。实验室结果显示炎症与CRP328mg/L。CT扫描显示左侧颈内动脉周围组织浸润增厚,颈动脉分叉,和颈总动脉,以及主动脉弓的周向增厚。左颈内动脉超声发现等回声壁增厚。在没有类固醇的情况下,症状在短时间内急剧改善。霍顿病,Takayasu\的疾病,和感染性血管炎没有保留,由于症状发作的短时间延迟,非典型回声,自发的改善。诊断为G-CSF诱发的大血管血管炎,颈动脉短暂性血管周围炎症(TIPIC)综合征。七天后,超声对照显示增厚浸润减少。G-CSFTIPIC是一种罕见的不良事件,应在G-CSF患者中牢记。
UNASSIGNED: We report a rare adverse event of transient perivascular inflammation of the carotid artery syndrome induced by granulocyte colony-stimulating factor injections. Recognition of this syndrome is important for physicians, to avoid the exposure of the causative medication, rule out differential diagnosis and delay the use of corticosteroids given the spontaneous improvement after discontinuation of the causative medication.
UNASSIGNED: A 73 year-old Caucasian woman presented with odynophagia, carotidynia, and fever 5 days following a granulocyte colony-stimulating factor (G-CSF) injection for chemotherapy-induced neutropenia in the setting of myelodysplastic syndrome. Examination showed painful swelling of the neck. Lab results showed inflammation with CRP 328 mg/L. A CT-scan revealed tissue infiltration thickening surrounding the left internal carotid artery, the carotid bifurcation, and the common carotid artery, as well as circumferential thickening of the aortic arch. Ultrasound of the left internal carotid artery found isoechoic wall thickening. Symptoms drastically improved without steroids in a short time period. Horton\'s disease, Takayasu\'s diseases, and infectious vasculitis were not retained due to the short time delay of symptoms onset, atypical echogenicity, and spontaneous improvement. A diagnosis of G-CSF-induced large vessel vasculitis transient perivascular inflammation of the carotid artery (TIPIC) syndrome was made. Seven days later, ultrasound control showed diminished thickening infiltration. G-CSF TIPIC is a rare adverse event that should be kept in mind in patients under G-CSF.