目的通过以适当的摩尔比混合氢键供体(HBD)和氢键受体(HBA)来形成DES。这些溶剂已被证明可以增强药物的溶解度,渗透性,和交付。本文的主要目的是回顾TheDES的这些优点。
结论:Thedes显示出独特的性质,如低毒性,生物降解性,改善的生物利用度和增强的难溶性活性药物成分的药物递送。它们在性质上也是生物相容的,这使得它们成为各种治疗应用的有希望的候选者。包括药物制剂,药物输送和其他生物医学用途。TheDES的开发和利用显示了药物研究的显著进步,为改善药物输送提供了新的机会。
方法:本研究是通过进行系统的文献综述,从索引数据库中确定相关论文进行的。本文引用和引用了许多研究和研究,以证明TheDES在增强药物溶解度方面的有效性,渗透性,和交付。所有选择的文章都是考虑到它们的意义而选择的,质量,以及解决问题的方法。
结果:因此,确定了可以以不同方式制定的各种TheDES:一个组件可以充当API的载体,HBD或HBA可以是API,HBD和HBA都可以是API,或DES的单个组分不具有治疗活性,但所得DES具有治疗活性。此外,TheDES还被认为可以增强不同API的药物递送和溶解度,包括NSAIDs,麻醉药物,抗真菌药,和其他人。
UNASSIGNED: TheDES are formed by mixing a Hydrogen Bond Donor (HBD) and a Hydrogen Bond Acceptor (HBA) in appropriate molar ratios. These solvents have been shown to enhance drug solubility, permeability, and delivery. The main objective of the present article is to review these advantages of
TheDES.
UNASSIGNED: TheDES show unique properties, such as low toxicity, biodegradability, improved bioavailability and enhanced drug delivery of poorly soluble active pharmaceutical ingredients. They are also biocompatible in nature which makes them a promising candidate for various therapeutic applications, including drug formulations, drug delivery and other biomedical uses. The development and utilization of TheDES shows significant advancement in pharmaceutical research, providing new opportunities for improving drug delivery.
UNASSIGNED: The current study was carried out by conducting a systematic literature review that identified relevant papers from indexed databases. Numerous studies and research are cited and quoted in this article to demonstrate the effectiveness of TheDES in enhancing drug solubility, permeability, and delivery. All chosen articles were selected considering their significance, quality, and approach to addressing issues.
UNASSIGNED: As a result, various
TheDES were identified that can be formulated in different ways: one component can act as a vehicle for an API, either HBD or HBA can be an API, both HBD and HBA can be APIs, or the individual components of DES are not therapeutically active but the resulting DES possesses therapeutic activity. Additionally,
TheDES were also recognized to enhance drug delivery and solubility for different APIs, including NSAIDs, anesthetic drugs, antifungals, and others.