未经证实:焦虑症非常普遍,对日常功能和生活质量产生负面影响。针对背外侧前额叶皮层(dlPFC)的经颅直流电刺激(tDCS),特别是在右半球影响灭绝学习;然而,潜在的神经机制是难以捉摸的。因此,我们的目的是研究右侧dlPFC的阴极tDCS刺激对健康参与者恐惧消退延迟期间神经活动和连接模式的影响.
未经评估:我们进行了为期两天的恐惧调节和灭绝程序。第一天,我们收集了与恐惧有关的自我报告,临床问卷,和恐惧获取过程中的皮肤电导反应。第二天,tDCS组的参与者(n=16)在fMRI前接受20分钟离线tDCS,然后在fMRI期间完成恐惧消退.对照组(n=18)的参与者跳过了tDCS,直接接受了fMRI以完成恐惧消退程序。进行了全脑探照灯分类和静息状态功能连接分析。
UNASSIGNED:恐惧消退期间的全脑探照灯分类显示,tDCS组左前背侧和腹侧胰岛和海马的威胁和安全线索的分类准确性高于对照组。从岛与dlPFC的功能连接,腹内侧前额叶皮质,tDCS后下顶叶小叶增加。
UNASSIGNED:右侧dlPFC上的tDCS可能充当远端连接区域之间信息交换的引物,从而增加刺激歧视。目前的研究不包括假小组,对照组的一名参与者未随机分组.因此,为了解决潜在的分配偏差,研究结果应在未来通过完全随机和假对照研究得到证实.
UNASSIGNED: Anxiety disorders are highly prevalent and negatively impact daily functioning and quality of life. Transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex (dlPFC), especially in the right hemisphere impacts extinction learning; however, the underlying neural mechanisms are elusive. Therefore, we aimed to investigate the effects of cathodal tDCS stimulation to the right dlPFC on neural activity and connectivity patterns during delayed fear extinction in healthy participants.
UNASSIGNED: We conducted a two-day fear conditioning and extinction procedure. On the first day, we collected fear-related self-reports, clinical questionnaires, and skin conductance responses during fear acquisition. On the second day, participants in the tDCS group (n = 16) received 20-min offline tDCS before fMRI and then completed the fear extinction session during fMRI. Participants in the control group (n = 18) skipped tDCS and directly underwent fMRI to complete the fear extinction procedure. Whole-brain searchlight classification and resting-state functional connectivity analyses were performed.
UNASSIGNED: Whole-brain searchlight classification during fear extinction showed higher classification accuracy of threat and safe cues in the left anterior dorsal and ventral insulae and hippocampus in the tDCS group than in the control group. Functional connectivity derived from the insula with the dlPFC, ventromedial prefrontal cortex, and inferior parietal lobule was increased after tDCS.
UNASSIGNED: tDCS over the right dlPFC may function as a primer for information exchange among distally connected areas, thereby increasing stimulus discrimination. The current study did not include a sham group, and one participant of the control group was not randomized. Therefore, to address potential allocation bias, findings should be confirmed in the future with a fully randomized and sham controlled study.