目的:肌肉减少症是一种以老年人肌肉损失为特征的病理改变。据报道,血脂异常与肌少症的关系存在争议。因此,本荟萃分析旨在探讨少肌症与血脂异常之间的关系.
方法:我们搜索了Cochrane库,WebofScience,PubMed,中国国家知识基础设施(CNKI),万芳,中国科技期刊数据库(VIP数据库)用于病例对照研究,以提取肌肉减少症和血脂异常之间的比值比(OR)和TC的MD(平均差)数据,LDL-C,HDL-C,TG,TG/HDL-C在少肌症和非少肌症之间。JBI(JoannaBriggs)指南用于评估质量。使用Excel2021、ReviewManager5.3和Stata16.0进行统计分析。
结果:20项研究纳入荟萃分析,其中19个被评价为良好的质量。肌少症与血脂异常关系的总OR为1.47,TC的MD值,LDL-C,HDL-C,TG,TG/HDL-C分别为1.10、1.95、1.27、30.13和0.16。在女性中,与非肉鸡相比,TC的MD,LDL-C,HDL-C,肌肉减少症的TG分别为-1.67、2.21、1.02、-3.18。在男性中,TC的MD,LDL-C,HDL-C,肌肉减少症和非肌肉减少症之间的TG分别为-0.51、1.41、5.77、-0.67。非中国地区肌肉减少症与血脂异常的OR为4.38,中国为0.9。在组(>60)中,肌少症和非肌少症的TCMD为2.63,而该组(20-60)为1.54。
结论:老年人血脂异常与肌肉减少有关,受到性的影响,地区和年龄。
OBJECTIVE: Sarcopenia is a pathological change characterized by muscle loss in older people. According to the reports, there is controversy on the relationship between dyslipidemia and sarcopenia. Therefore, this meta-analysis aimed to explore the association between sarcopenia and dyslipidemia.
METHODS: We searched the Cochrane Library, Web of Science, PubMed, China National Knowledge Infrastructure (CNKI), Wan Fang, China Science and Technology Journal Database (VIP Database) for case‒control studies to extract data on the odds ratio (OR) between sarcopenia and dyslipidemia and the MD(mean difference) of
TC, LDL-C, HDL-C, TG, and TG/HDL-C between sarcopenia and nonsarcopenia. The JBI(Joanna Briggs) guidelines were used to evaluate the quality. Excel 2021, Review Manager 5.3 and Stata 16.0 were used for the statistical analysis.
RESULTS: Twenty studies were included in the meta-analysis, 19 of which were evaluated as good quality. The overall OR of the relationship between sarcopenia and dyslipidemia was 1.47, and the MD values of
TC, LDL-C, HDL-C, TG, and TG/HDL-C were 1.10, 1.95, 1.27, 30.13, and 0.16 respectively. In female, compared with the non-sarcopnia, the MD of
TC, LDL-C, HDL-C, TG of sarcopenia were - 1.67,2.21,1.02,-3.18 respectively. In male, the MD of
TC, LDL-C, HDL-C, TG between sarcopenia and non-sarcopenia were - 0.51, 1.41, 5.77, -0.67. The OR between sarcopenia and dyslipidemia of the non-China region was 4.38, and it was 0.9 in China. In the group(> 60), MD of
TC between sarcopenia and non-sarcopenia was 2.63, while it was 1.54 in the group(20-60).
CONCLUSIONS: Dyslipidemia was associated with sarcopenia in the elderly, which was affected by sex, region and age.