胎儿早期(受孕后9-13周)的形态测量分析对于评估正常的大脑生长至关重要。在这项研究中,我们使用在京都大学保存的21个样本的高分辨率T1加权磁共振成像(MRI)扫描,评估了这一时期胎儿大脑的形态学和形态学变化.MRI剖面图(冠状,中矢状,和水平部分)和整个大脑的3D重建显示其外部形态和内部结构的顺序变化。大脑的宏观外部视图,侧脑室和脉络丛,脑壁,基底神经节和丘脑,和call体进行了评估。大脑皮层的发育,白质微观结构,使用MRI扫描可以很好地表征基底神经节。随着大脑生长的进展,脑岛变得明显并给人留下了深刻的印象。一个厚厚的,在高信号强度下,密集的细胞心室/室下区和神经节隆起变得明显。我们检测到重要标志的出现,这些标志可能是胎儿早期细分过程中的候选者;首先在冠部长度(CRL)为62mm的样本中检测到call体。在CRL为114mm的样品中观察到皮质内侧部分的原发性沟(扣带沟)。在小脑,半球,后外侧裂,小脑两半的联合,在CRL为43.5mm的样品中观察到and的定义,同时,在CRL为56mm的样品中出现初级裂缝,在CRL为75mm的样品中出现锥体外系裂缝。体积,线性,角度测量揭示了综合和区域发展,增长,和早期胎儿期大脑结构的分化。胎儿早期在形态上和形态上都不均匀。大脑的比例(长度/高度)和大脑相对于大脑侧视标准线的角度,这可能反映了大脑的生长和C形形成,可能是细分早期胎儿期的候选人。未来的精确分析必须在胎儿早期建立大脑的分期系统。这项研究提供了对大脑结构的见解,允许与功能成熟相关,并促进早期发现脑损伤和异常发育。
Morphometric analyses in the early foetal phase (9-13 postconceptional week) are critical for evaluating normal brain growth. In this study, we assessed sequential morphological and morphometric changes in the foetal brain during this period using high-resolution T1-weighted magnetic resonance imaging (MRI) scans from 21 samples preserved at Kyoto University. MRI sectional views (coronal, mid-sagittal, and horizontal sections) and 3D reconstructions of the whole brain revealed sequential changes in its external morphology and internal structures. The cerebrum\'s gross external view, lateral ventricle and choroid plexus, cerebral wall, basal ganglia and thalamus, and corpus callosum were assessed. The development of the cerebral cortex, white matter microstructure, and basal ganglia can be well-characterized using MRI scans. The insula became apparent and deeply impressed as brain growth progressed. A thick, densely packed cellular ventricular/subventricular zone and ganglionic eminence became apparent at high signal intensity. We detected the emergence of important landmarks which may be candidates in the subdivision processes during the early foetal period; the corpus callosum was first detected in the sample with crown-rump length (CRL) 62 mm. A primary sulcus on the medial part of the cortex (cingulate sulcus) was observed in the sample with CRL 114 mm. In the cerebellum, the hemispheres, posterolateral fissure, union of the cerebellar halves, and definition of the vermis were observed in the sample with CRL 43.5 mm, alongside the appearance of a primary fissure in the sample with CRL 56 mm and the prepyramidal fissure in the sample with CRL 75 mm. The volumetric, linear, and angle measurements revealed the comprehensive and regional development, growth, and differentiation of brain structures during the early foetal phase. The early foetal period was neither morphologically nor morphometrically uniform. The cerebral proportion (length/height) and the angle of cerebrum to the standard line at the lateral view of the cerebrum, which may reflect the growth and C-shape formation of the cerebrum, may be a candidate for subdividing the early foetal period. Future precise analyses must establish a staging system for the brain during the early foetal period. This study provides insights into brain structure, allowing for a correlation with functional maturation and facilitating the early detection of brain damage and abnormal development.