目的:定义系统性和心脏淀粉样变性(CA)的流行病学是当代的挑战。本研究旨在估计威尼托地区(500万居民,意大利东北部)。
方法:使用国际疾病分类(ICD-9)代码在2010年至2020年的威尼托地区鉴定AH。AH被定义为任何住院,出院摘要报告ICD-9代码为系统性淀粉样变性。CA的住院定义为ICD-9代码为系统性淀粉样变性和ICD-9代码为心力衰竭的记录。心肌病或心律失常。还提取了腕管综合征(CTS)手术的医院/门诊。使用5年的缓冲估计AH发病率。
结果:在2015-2020年的时间范围内,AH的发生率为每106例23.5例(95%置信区间,CI,21.8;25.3),主要影响患者>65岁(76.2%)和男性(63.5%),呈逐步增长的趋势(每年增长17%,95%CI12;22%)。2020年AH的10年患病率为124.5/106(95%CI114.9;134.8)。2020年,每年住院的CA流行病例约占所有病例的70%(159/228),主要患者>65岁,男性。在多次CTS手术的患者中,在中位数为3.9年后的913年发现了随后的心脏病代码,男性比女性更常见(463/6.5267.1%对450/11.4063.9%)。
结论:在威尼托,我们记录了AH发病率的显着增加趋势,随着患病率估计的增加。对先前多次CTS手术的选定患者进行量身定制的筛查可能是合理的。
OBJECTIVE: Defining the epidemiology of systemic and cardiac amyloidosis (CA) is a contemporary challenge. The present study aimed to estimate incidence and time trends in amyloidosis-related hospitalizations (AH) in Veneto Region (5 million inhabitants, Northeastern Italy).
METHODS: International Classification of Diseases (ICD-9) codes were used to identify AH in Veneto from 2010 to 2020. AH were defined as any hospitalization with a discharge summary reporting an ICD-9 code for systemic amyloidosis. Hospitalization for CA was defined as records with ICD-9 code for systemic amyloidosis and ICD-9 code for heart failure,cardiomyopathy or arrhythmia. Hospital/outpatient encounters for carpal tunnel syndrome (CTS) surgeries also were extracted. AH incidence was estimated using a buffer of 5 years.
RESULTS: In the time range 2015-2020, the incidence rate of AH was 23.5 cases per 106 (95% confidence interval, CI, 21.8; 25.3), mainly affecting patients>65 years (76.2%) and males (63.5%), with a progressively increasing trend (percent annual increase 17%, 95% CI 12; 22%). The 10 year prevalence of AH in 2020 was 124.5 per 106 (95% CI 114.9; 134.8). In 2020, annual hospitalized prevalent cases of CA were about 70% of all cases (159/228), mainly patients >65 years and males. Among patients with multiple CTS surgeries, a subsequent code for cardiac disease was found in 913 after a median of 3.9 years, more frequently in men than in women (463/6.526 7.1% versus 450/11.406 3.9%).
CONCLUSIONS: In Veneto, we recorded a significantly increasing trend in the incidence of AH, with concordant increasing prevalence estimates.