目的:皮质脑淀粉样蛋白病,阿尔茨海默病的标志,在特发性正常压力脑积水(iNPH)中也观察到。这项研究的目的是比较iNPH患者和健康受试者的11C-PIBPET/CT保留模式。
方法:对13例iNPH患者的11C-PIBPET/CT保留模式进行了比较,与正常对照人群相比。对图像进行视觉分析,并对灰质和白质(WM)从1至4(轻微至非常高的PIB保留)进行评分。在两组中分别分析了幕下和幕上区域的评分。一份全面的临床报告以积极的观点提出,负,或者模棱两可。
结果:11C-PIBPET/CT扫描报告8例阴性,3例阳性,2例模棱两可。13例患者中有5例显示至少一个皮质区域具有PIB保留,其强度高于对照组。总的来说,iNPH的白质(WM)PIB保留评分低于对照组,显示在幕下WM(92/104vs54/56;p<.05)的统计学差异,并且在幕上区域的趋势较低(70/84vs122/156,p=.327),特别是在上脑室周围区域(25/28vs40/52;p=.134)。
结论:NPH中的PIB保留模式似乎不同,与正常人相比。NPHWM中的PIB保留似乎不如健康受试者强烈,它们在皮质区域显示出更高程度的PIB保留。这一点值得考虑。
OBJECTIVE: Cortical cerebral amyloid disease, a hallmark of Alzheimer\'s disease, has also been observed in idiopathic normal pressure hydrocephalus (iNPH). The aim of this study was to compare the 11C-PIB PET/CT retention pattern in iNPH patients and healthy subjects.
METHODS: A comparison was made of the 11C-PIB PET/CT retention pattern in 13 iNPH patients selected for surgical deviation, compared to a normal control population. Images were visually analyzed and scored for gray matter and white matter (WM) from 1 to 4 (slight to very high PIB retention). The scoring was analyzed in both groups separately for infra- and supra-tentorial regions. A comprehensive clinical report was presented in terms of positive, negative, or equivocal.
RESULTS: 11C-PIB PET/CT scan were reported as negative in 8, positive in 3, and equivocal in 2. Five of 13 patients showed at least one cortical area with PIB retention with an intensity higher than that observed in the control group. Overall, white matter (WM) PIB retention of iNPH scored lower than in the control group, showing a statistically significant difference in the infratentorial WM (92/104 vs 54/56; p<.05) and a tendency to be lower in the supratentorial regions (70/84 vs 122/156, p=.327), in particular in the upper periventricular region (25/28 vs 40/52; p=.134).
CONCLUSIONS: The PIB retention pattern seems to be different in NPH, compared to normal subjects. PIB retention in WM of NPH appears less intense than in healthy subjects, and they show a higher degree of PIB retention in cortical regions. This deserves to be taken it into account.