未经证实:关于上尿路尿路上皮癌(UTUC)死亡原因的研究很少发表。我们试图探索当代UTUC幸存者的死亡模式。
UNASSIGNED:我们进行了一项回顾性队列研究,涉及国家癌症研究所监测的上尿路癌患者,流行病学,和最终结果(SEER)数据库(2000年和2015年)。我们使用标准化死亡率比(SMR)来比较普通人群中UTUC患者的死亡率和过度绝对风险(EAR)来量化疾病特异性死亡负担。
未经批准:共有10,179名UTUC患者,包括7133人死亡,包括在我们的研究中。总的来说,302例(17.17%)患有局部疾病的患者死于UTUC;然而,死于其他原因的患者死于UTUC的可能性增加4.8倍(n=1,457[82.83%]).心血管疾病是最常见的非癌症死亡原因(n=393[占所有死亡的22.34%]);SMR,1.22;95%置信区间[CI],1.1-1.35;EAR,35.96)。共有4,046例(69.99%)区域分期患者在随访中死亡,其中1,413人(34.92%)死于UTUC,其中1,082人(26.74%)死于非癌症原因。UTUC是主要的死亡原因(SMR,242.48;95%CI,230-255.47;耳朵,542.47),其次是非肿瘤原因(SMR,1.18;95%CI,1.11-1.25;耳朵,63.74).大多数远隔期患者(94.94%)在初次诊断后3年内死亡。尽管UTUC是导致死亡的主要原因(n=721[54.29%]),这些患者也比普通人群有更高的非癌症死亡风险(SMR,2.08;95%CI,1.67-2.56;耳朵,288.26)。
UNASSIGNED:非UTUC死亡占局部疾病患者UTUC幸存者的82.48%。区域/远处阶段的患者最有可能死于UTUC;然而,死于不可忽视的非癌症原因的风险增加。这些数据提供了对UTUC患者死亡原因的最新和最全面的评估。
UNASSIGNED: Very few studies have been published on the causes of death of upper tract urothelial carcinoma (UTUC). We sought to explore the mortality patterns of contemporary UTUC survivors.
UNASSIGNED: We performed a retrospective cohort study involving patients with upper urinary tract carcinoma from the National Cancer Institute\'s Surveillance, Epidemiology, and End Results (SEER) database (2000 and 2015). We used standardized mortality ratios (SMRs) to compare death rates among patients with UTUC in the general population and excess absolute risks (EARs) to quantify the disease-specific death burden.
UNASSIGNED: A total of 10,179 patients with UTUC, including 7,133 who died, were included in our study. In total, 302 (17.17%) patients with the localized disease died of UTUC; however, patients who died from other causes were 4.8 times more likely to die from UTUC (n = 1,457 [82.83%]). Cardiovascular disease was the most common non-cancer cause of death (n = 393 [22.34% of all deaths]); SMR, 1.22; 95% confidence intervals [CI], 1.1-1.35; EAR, 35.96). A total of 4,046 (69.99%) patients with regional stage died within their follow-up, 1,413 (34.92%) of whom died from UTUC and 1,082 (26.74%) of whom died from non-cancer causes. UTUC was the main cause of death (SMR, 242.48; 95% CI, 230-255.47; EAR, 542.47), followed by non-tumor causes (SMR, 1.18; 95% CI, 1.11-1.25; EAR, 63.74). Most patients (94.94%) with distant stage died within 3 years of initial diagnosis. Although UTUC was the leading cause of death (n = 721 [54.29%]), these patients also had a higher risk of death from non-cancer than the general population (SMR, 2.08; 95% CI, 1.67-2.56; EAR, 288.26).
UNASSIGNED: Non-UTUC deaths accounted for 82.48% of UTUC survivors among those with localized disease. Patients with regional/distant stages were most likely to die of UTUC; however, there is an increased risk of dying from non-cancer causes that cannot be ignored. These data provide the latest and most comprehensive assessment of the causes of death in patients with UTUC.