■松果体区病变的切除具有挑战性,和治疗策略对他们的去除仍然存在争议。本研究旨在确定松果体区病变的特征和最佳治疗策略。
■这项回顾性研究回顾了101例松果体区病变患者的治疗方法,观察到不同的特点和治疗策略。
■总切除率无统计学差异,并发症,脑积水组和非脑积水组之间的预后结果,除了脑积水组患者年龄较小,儿科患者颅内感染水平升高.松果体区病变继发的病变和脑积水的治疗是治疗策略的两个组成部分。对于病变的管理,术前诊断为生殖细胞瘤或非生殖细胞瘤,选择切除或诊断性放疗来处理松果体区病变。内窥镜辅助手术提供了更高的总切除率。对于脑积水的管理,内镜下第三脑室造瘘术(ETV)治疗效果较好。此外,放疗或切除前脑脊液(CSF)分流并没有改善预后结果,但对于严重脑积水的患者是必要的。Logistic回归分析表明,年龄,病变大小,再手术率,颅内并发症是预后结果的预测因素。
■应更多关注松果体区病变继发脑积水的小儿颅内感染,放疗或切除前的脑脊液转流并不能促进预后结果,但对于严重脑积水的患者是必要的。年龄,病变大小,再手术率,颅内并发症可能是预后结果的预测因素。最重要的是,基于术前诊断(非生殖细胞瘤和生殖细胞瘤)的松果体区病变的手术算法是有用的,特别是对于发展中国家。
UNASSIGNED: The removal of pineal region lesions are challenging, and therapeutic strategies for their removal remain controversial. The current study was conducted to identify the characteristics and the optimal therapeutic strategies for pineal region lesions.
UNASSIGNED: This retrospective study reviewed the treatments of 101 patients with pineal region lesions, and different characteristics and therapeutic strategies were observed.
UNASSIGNED: There were no statistical differences in the total resection ratio, complications, and prognosis outcomes between the hydrocephalus group and non-hydrocephalus group, except patients in the hydrocephalus group were younger and pediatric patients had an increased level of intracranial infections. Treatments of lesions and hydrocephalus secondary to pineal region lesions were two integral parts to therapeutic strategies. For the management of lesions, germinoma or non-germinoma were diagnosed preoperatively, and resection or diagnostic radiation were chosen to deal with pineal region lesions. Endoscopic-assisted surgery provided a higher total resection rate. For the management of hydrocephalus, endoscopic third ventriculostomy (ETV) had the better therapeutic effect. Additionally, cerebrospinal fluid (CSF) diversion before radiotherapy or resection did not improve prognosis outcome, but it was necessary for patients with severe hydrocephalus. Logistical regression analysis indicated that age, lesion size, reoperation ratio, and intracranial complications were predictors of prognosis outcome.
UNASSIGNED: More attention should be paid to intracranial infections in pediatric patients with hydrocephalus secondary to pineal region lesions, and CSF diversion before radiotherapy or resection did not promote prognosis outcome, but it was necessary for patients with severe hydrocephalus. Age, lesion size, reoperation ratio, and intracranial complications may be the predictors of prognosis outcome. Most importantly, the surgical algorithm for pineal region lesions which was based on preoperatively diagnosis (non-germinoma and germinoma) is useful, especially for developing countries.