Substance‐related disorders

  • 文章类型: Journal Article
    目标:接受酒精和其他药物(AOD)治疗的年轻人经历了很高的治疗脱离率,导致较差的结果。为了改善结果,确定与治疗保留相关的因素很重要.这项研究测量了客户特征之间的关系,治疗特点,年轻人的临床严重程度测量和完成治疗。
    方法:这项研究是对新南威尔士州居民和社区AOD服务中常规收集的数据集的回顾性分析,澳大利亚。使用从酒精和其他药物机构网络(NADA)数据库中常规收集的数据。纳入的个体年龄为10-24岁,在2012年至2023年之间获得治疗(n=17474)。
    方法:变量包括与客户端相关的特征,服务特征和临床严重程度的基线测量[Kessler-10(K10),EUROHIS-QoL,严重依赖量表(SDS)]。多变量二元逻辑回归模型评估了这些特征与治疗完成之间的关系。
    结果:接受社区治疗的青少年完成率最高(57%),接受住院治疗的青少年完成率最低(35%)。在基于社区的治疗中,青少年[调整比值比(adjOR)=0.71,P<0.001]和成年人(adjOR=0.70,P<0.001)的多物质使用与治疗完成呈负相关,接受住院治疗的青少年(adjOR=0.62,P=0.006),住房不安全(社区治疗中的青少年,adjOR=0.61,P=0.001;社区治疗的成年人,adjOR=0.77,P=0.002;接受住院治疗的青少年,adjOR=0.42,P=0.005)。在社区(adjOR=1.81,P<0.001)和住院治疗(adjOR=1.72,P<0.001)的成年人中,参加青年特定服务与较高的治疗完成率相关。在整个治疗组中确定了治疗完成的不同相关性,反映不同背景下人口和/或需求的差异。
    结论:在新南威尔士州,澳大利亚,在2012年至2023年期间,接受酒精和其他药物治疗的年轻人中,不到一半完成了治疗,在那些面临诸如多物质使用和住房不安全等障碍的人中,完成率较低。
    OBJECTIVE: Young people accessing alcohol and other drug (AOD) treatment experience high rates of treatment disengagement, contributing to poorer outcomes. To improve outcomes, it is important to identify factors associated with treatment retention. This study measured the relationships between client characteristics, treatment characteristics, clinical severity measures and completion of treatment among young people.
    METHODS: This study was a retrospective analysis of routinely collected data set in residential- and community-based AOD services in New South Wales, Australia. Routinely collected data from the Network of Alcohol and Other Drug Agencies\' (NADA) database were used. Included individuals were aged 10-24 years and accessed treatment between 2012 and 2023 (n = 17 474).
    METHODS: Variables included client-related characteristics, service characteristics and baseline measures of clinical severity [Kessler-10 (K10), EUROHIS-QoL, severity of dependence scale (SDS)]. Multivariable binary logistic regression models assessed the relationships between these characteristics and treatment completion.
    RESULTS: Rates of treatment completion were highest among adolescents in community-based treatment (57%) and lowest among young adults in residential treatment (35%). Polysubstance use was negatively associated with treatment completion among adolescents [adjusted odds ratio (adjOR) = 0.71, P < 0.001] and adults (adjOR = 0.70, P < 0.001) in community-based treatment, and adolescents in residential treatment (adjOR = 0.62, P = 0.006), as was housing insecurity (adolescents in community treatment, adjOR = 0.61, P = 0.001; adults in community treatment, adjOR = 0.77, P = 0.002; adolescents in residential treatment, adjOR = 0.42, P = 0.005). Attending youth-specific services was associated with higher treatment completion rates among adults in community-based (adjOR = 1.81, P < 0.001) and residential treatment (adjOR = 1.72, P < 0.001). Varying correlates of treatment completion were identified throughout treatment groups, reflecting the differences in population and/or needs across contexts.
    CONCLUSIONS: In New South Wales, Australia, fewer than half of young people accessing alcohol and other drug treatment between 2012 and 2023 completed treatment, and completion rates were lower among those facing barriers such as polysubstance use and housing insecurity.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    尽管酒精和其他药物的使用越来越成为政策和研究工作的重点,在卫生保健和社区环境中,识别和应用基于证据的策略以最大程度地减少酒精和其他药物的危害存在挑战。这些挑战包括有限的可用研究,不同设置的可变性,研究证据与其预期设置之间缺乏“契合度”。在这篇评论中,我们描述了一种新颖的方法来开发和评估,可持续战略,以加强将循证活动纳入卫生服务和社区环境。我们的方法涉及四个关键原则:(i)确定基于证据的酒精和其他药物危害最小化战略;(ii)与当地专家合作以确定和调整战略;(iii)在现有实践/基础设施中实施战略以建立可持续性;(iv)使用可持续的共同设计成果措施,包括基于价值的医疗保健原则来衡量吸收,可行性和可接受性,健康结果和经济影响。我们建议,这种方法提供了一条前进的道路,以提高卫生服务和社区环境中研究的相关性和适用性,并有可能在其他部门应用。
    Although alcohol and other drug use is increasingly the focus of policy and research efforts, there are challenges identifying and applying evidence-based strategies to minimise harms for alcohol and other drugs in health care and community settings. These challenges include limited available research, variability across settings, and lack of \'fit\' between research evidence and their intended settings. In this commentary, we describe a novel approach to develop and evaluate tailored, sustainable strategies to enhance the uptake of evidence-based activities into health services and community settings. Our approach involves four key principles: (i) identifying evidence-based alcohol and other drug harm minimisation strategies; (ii) partnering with local experts to identify and tailor strategies; (iii) implementing strategies into existing practice/infrastructure to build in sustainability; and (iv) using sustainable co-designed outcome measures including value-based health-care principles to measure uptake, feasibility and acceptability, health outcomes and economic implications. We propose that this approach offers a way forward to enhance the relevance and suitability of research in health services and community settings and has potential to be applied in other sectors.
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  • 文章类型: Journal Article
    最近儿科和青少年阿片类药物死亡人数的增加迫切需要及早考虑可能的阿片类药物暴露以及针对这些独特人群的特定诊断和管理策略和干预措施。与成年人相比,儿科接触方法包括意外摄入,处方误用,和家庭曝光。早期识别,适当的诊断评估,讨论了这种人口统计学中阿片类药物毒性的专门治疗方法。一个关键的焦点是纳洛酮,阿片类药物中毒的基本药物,解决其在儿科使用中的独特挑战。独特的儿科考虑因素包括在我们最年轻的人群中识别意外摄入,关键的社会方面,包括家庭安全和故意暴露,和减少伤害战略,主要通过纳洛酮分发和安全用药实践教育。它要求采取多方面的方法,包括创建儿科特定指南,与儿童阿片类药物危机作斗争,并努力降低阿片类药物过量的发病率和死亡率。
    Recent increases in pediatric and adolescent opioid fatalities mandate an urgent need for early consideration of possible opioid exposure and specific diagnostic and management strategies and interventions tailored to these unique populations. In contrast to adults, pediatric methods of exposure include accidental ingestions, prescription misuse, and household exposure. Early recognition, appropriate diagnostic evaluation, along with specialized treatment for opioid toxicity in this demographic are discussed. A key focus is on Naloxone, an essential medication for opioid intoxication, addressing its unique challenges in pediatric use. Unique pediatric considerations include recognition of accidental ingestions in our youngest population, critical social aspects including home safety and intentional exposure, and harm reduction strategies, mainly through Naloxone distribution and education on safe medication practices. It calls for a multifaceted approach, including creating pediatric-specific guidelines, to combat the opioid crisis among children and to work to lower morbidity and mortality from opioid overdoses.
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  • 文章类型: Journal Article
    在埃塞俄比亚,非传染性疾病占过早死亡率的18.3%,消费家庭支出的23%,占本地生产总值的1.8%。危险因素如酒精,khat,大麻的使用呈上升趋势,并与很大一部分非传染性疾病相关。相关的非传染性疾病包括抑郁症,焦虑,高血压,冠心病,和心肌梗塞。精神健康和药物滥用障碍的多面性需要多维度干预。本文借鉴了参与者的观察和文献综述来考察政策,交付模型,以及从联邦卫生部(FMOH)将精神健康和药物滥用(MH/SA)服务纳入埃塞俄比亚初级保健的经验中吸取的经验教训。2019年,FMOH制定了针对非传染性疾病和心理健康的国家战略,以覆盖其人口。埃塞俄比亚在政府部门内整合了MH/SA各级服务,强调初级卫生保健。FMOH推出了埃塞俄比亚初级卫生保健临床指南,其中包括提供非传染性疾病服务,标准化初级卫生保健一级的护理。迄今为止,该指南已由800多个卫生中心实施,预计将提高服务质量和健康结果。现有的初级保健计划扩大到包括预防,早期发现,治疗,和MH/SA的康复。这包括培训和利用一系列卫生专业人员,包括传统的治疗师和那些来自基于信仰的机构和社区组织。共有244个保健中心完成了心理健康差距行动计划(mhGAP)的培训。2020年,5,000名城市健康推广工作者(HEW)参加了进修培训,其中包括心理健康和非传染性疾病。正在为农村卫生工作者制定类似的课程。埃塞俄比亚的经验有许多关于利益相关者买入的经验教训,角色,培训,物流,和可转移到其他国家的可持续性。教训包括公共医疗机构领导人的“购买”需要持续和持续的培养。确保MH/SA服务的逐步和校准集成,以便任务共享不会被视为“任务转储”。“对新培训人员的监督和指导对于提供优质护理和获得技能至关重要。
    In Ethiopia, noncommunicable diseases (NCDs) represent 18.3% of premature mortality, consume 23% of the household expenditures, and cost 1.8% of the gross domestic product. Risk factors such as alcohol, khat, and cannabis use are on the rise and are correlated with a substantial portion of NCDs. Associated NCDs include depression, anxiety, hypertension, coronary heart disease, and myocardial infarction. The multi-faceted nature of mental health and substance abuse disorders require multi-dimensional interventions. The article draws upon participant observation and literature review to examine the policies, delivery models, and lessons learned from the Federal Ministry of Health (FMOH) experience in integrating Mental Health and Substance Abuse (MH/SA) services into primary care in Ethiopia. In 2019, FMOH developed national strategies for both NCDs and mental health to reach its population. Ethiopia integrated MH/SA services at all levels within the government sector, with an emphasis on primary health care. FMOH launched the Ethiopian Primary Health Care Clinical Guidelines, which includes the delivery of NCD services, to standardize the care given at the primary health care level. To date, the guidelines have been implemented by over 800 health centers and are expected to improve the quality of service and health outcomes. Existing primary care programs were expanded to include prevention, early detection, treatment, and rehabilitation for MH/SA. This included training and leveraging an array of health professionals, including traditional healers and those from faith-based institutions and community-based organizations. A total of 244 health centers completed training in the Mental Health Gap Action Programme (mhGAP). In 2020, 5,000 urban Health Extension Workers (HEWs) participated in refresher training, which includes mental health and NCDs. A similar curriculum for rural health workers is in development. Ethiopia\'s experience has many lessons learned about stakeholder buy-in, roles, training, logistics, and sustainability that are transferable to other countries. Lessons include that \"buy-in\" by leaders of public health care facilities requires consistent and persistent nurturing. Ensure the gradual and calibrated integration of MH/SA services so that the task-sharing will not be viewed as \"task dumping.\" Supervision and mentorship of the newly trained is important for the delivery of quality care and acquisition of skills.
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  • 文章类型: Journal Article
    评估1型糖尿病(T1D)的年轻人(18-35岁)的酒精和非法药物使用对闪光葡萄糖监测仪传感器葡萄糖(SG)读数的影响。
    从墨尔本的三级转诊医院门诊部招募了20名患有T1D的年轻人,澳大利亚进行为期6周的前瞻性观察性研究,使用闪光血糖监测(FGM)。分析了使用物质天数(SUED)与不使用物质天数(非SUEDS)的比较。主要结果是平均SG值的差异,匹配的SUED与非SUED之间的标准偏差和分钟/24小时时间超出范围(SG<3.9mmol/L或>10.0mmol/L)。还进行了HbA1c对SG值的主要影响的相互作用模型。
    SUEDS和非SUEDS的主要结局指标没有差异。然而,对于平均SG,非SUED和SUED之间的HbA1c和血糖学回归系数存在差异,超出范围的时间和SG>10mmol/L的时间在非SUEDS和平均SG≥40g酒精的天数之间也发现了这种差异。
    虽然SUED和非SUED的血糖测量在主要结局上没有差异,与对照组相比,在物质使用后的24小时内,发现HbA1C是葡萄糖模式的可靠预测因子。患有T1D的年轻人需要在使用物质后监测和响应他们的葡萄糖水平,并参与危害最小化实践,而与基线血糖控制无关。
    UNASSIGNED: To assess the effects of alcohol and illicit drug use in young adults (age 18-35) with type 1 diabetes (T1D) on flash glucose monitor sensor glucose (SG) readings.
    UNASSIGNED: Twenty young adults with T1D were enrolled from a tertiary referral hospital outpatient department in Melbourne, Australia for a 6-week prospective observational study using flash glucose monitoring (FGM). Glucometrics comparing substance using days (SUEDs) to those without substance use (non-SUEDS) were analysed. The primary outcomes were the difference in mean SG values, its standard deviation and minutes/24-h period out of range (SG <3.9 mmol/L or >10.0 mmol/L) between matched SUEDs vs non-SUEDs. An interaction model with the primary effect of HbA1c on SG values was also performed.
    UNASSIGNED: There were no differences in the primary outcome measures between SUEDS and non-SUEDs. However, there were differences in the regression coefficients for HbA1c and glucometrics between non-SUEDs and SUEDs for mean SG, time out of range and time with SG > 10 mmol/L. This difference was also identified between non-SUEDS and days of ≥40 g alcohol for mean SG.
    UNASSIGNED: While there was no difference between glucometrics for SUEDs and non-SUEDs on primary outcomes, HbA1C was found to be a less reliable predictor of glucose patterns in the 24-h period following substance use than control days. Young adults with T1D need to monitor and respond to their glucose levels following substance use and engage in harm minimisation practices irrespective of baseline glucose control.
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  • 文章类型: Journal Article
    目的:本文的目的是系统地回顾与实施同伴教育以促进监狱中的健康和健康行为有关的现有文献。
    方法:作者对Medline进行了叙述性系统综述,EMBASE,CINAHL,Psychinfo,WebofScience和Cochrane数据库。手工搜索相关期刊和参考文献清单,以查找要包含在评论中的相关文章。在找到的摘要中,对于那些被认为可能符合审查纳入标准的论文,我们检索了全文论文。
    结果:总共确定了3,033篇摘要,从而检索到46篇全文文章,其中十项被列入审查范围。监狱中的同伴教育会对态度产生影响,知识,和关于艾滋病毒风险行为的行为意向。研究结果对于同伴教育对非法药物使用和注射行为的影响尚无定论。很少有研究评估同伴教育对精神疾病的影响,肥胖,饮食,吸烟,或慢性身体疾病的自我管理。
    结论:同伴教育可有效降低HIV传播风险。对心理健康问题的同伴教育可能是一种耻辱,提供进一步研究活动的机会。同伴教育对非法药物使用行为的影响,肥胖,饮食,吸烟,慢性身体疾病的自我管理也提供了进一步的研究机会。还缺乏评估积极的同伴教育者参与卫生服务提供和组织的模型的研究。
    OBJECTIVE: The purpose of this paper is to review systematically the available literature relating to the implementation of peer education to promote health and healthy behaviour in prisons.
    METHODS: The authors undertook a narrative systematic review of Medline, EMBASE, CINAHL, Psychinfo, Web of Science and Cochrane databases. Relevant journals and reference lists were hand searched for relevant articles to be included in the review. Of the abstracts found, full-text papers were retrieved for those papers deemed as possibly fulfilling the inclusion criteria of the review.
    RESULTS: A total of 3,033 abstracts were identified leading to 46 full-text articles being retrieved, of which ten were included in the review. Peer education in prisons can have an impact on attitudes, knowledge, and behaviour intention regarding HIV risk behaviour. The research findings were inconclusive for the impact of peer education upon illicit drug use and injecting practice. There was a paucity of research evaluating the impact of peer education upon mental ill health, obesity, diet, smoking, or self-management of chronic physical diseases.
    CONCLUSIONS: Peer education is effective in reducing risk of HIV transmission. It is possible that peer education for mental health issues is stigmatising, presenting an opportunity for further research activity. The impact of peer education upon illicit drug use practice, obesity, diet, smoking, and self-management of chronic physical diseases also presents further research opportunities. Research evaluating models of active peer educator involvement in health service delivery and organisation is also lacking.
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  • 文章类型: Editorial
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