目的:中心性浆液性脉络膜视网膜病变(CSCR)是一种病因不明的眼病,表现为视力下降,脉络膜增厚(布鲁赫膜和脉络膜巩膜边界之间的距离),和视网膜下液渗漏.在本研究中,目的是研究相关的肌腱蛋白C的作用,金属蛋白-1,BAX,BCL2、亚脂肪素和反前列腺素分子在CSCR发病机制中的作用。
方法:纳入30例CSCR患者和30例对照。通过光学相干断层扫描成像诊断CSCR。在禁食过夜后从所有参与者收集5mL血液样品。用酶联免疫吸附测定(ELISA)方法研究血液样品中的化合物。
结果:发现与对照组相比,患有CSCR的患者黄斑增厚(P:0.08),并且视力显着降低(P:0.034)。关于血清参数,生腱蛋白C有统计学上的显著增加,金属蛋白-1,BAX,与对照相比,BCL2、亚脂肪素和反前列腺素水平。我们发现黄斑厚度与生腱蛋白C呈正相关(r+0.670,P<0.001),金属蛋白-1(r+0.714,P<0.001),巴克斯,BCL2(r+0.771,P<0.001),亚脂肪素和asprosin水平与视力和生腱蛋白C之间呈负相关(r0.605P<0.001),金属蛋白-1(r+0.704,P<0.001),巴克斯,BCL2(r+0.738,P<0.001),亚脂肪素和反前列腺素水平。
结论:本文研究的分子与视力呈负相关,与黄斑厚度呈正相关,提示这些分子可能在CSCR的发病机制中起作用。因此,我们预测,这些分子可能是未来CSCR诊断和随访的新候选者。
OBJECTIVE: Central serous chorioretinopathy (CSCR) is an eye disease of unknown etiology that presents with reduced visual acuity, choroidal thickening (distance between Bruch\'s membrane and the chorioscleral border), and subretinal fluid leakage. In the present study, the goal was to investigate the role of the interrelated tenascin C, metalloprotein-1, BAX, BCL2,
subfatin and asprosin molecules in the pathogenesis of CSCR.
METHODS: Thirty CSCR patients and 30 controls were included. CSCR was diagnosed by optical coherence tomography imaging. A 5mL blood sample was collected from all participants after overnight fasting. Compounds in the blood samples were studied with the Enzyme-Linked Immunosorbent Assay (ELISA) method.
RESULTS: Patients with CSCR were found to have macular thickening (P: 0.08) and statistically significantly reduced visual acuity (P: 0.034) compared to controls. With regard to serum parameters, there were statistically significant increases in tenascin C, metalloprotein-1, BAX, BCL2,
subfatin and asprosin levels compared to controls. We found a positive correlation between macular thickness and tenascin C (r+0.670, P<0.001), metaloprotein-1 (r+0.714, P<0.001), BAX, BCL2 (r+0.771, P<0.001),
subfatin and asprosin levels and a negative correlation between visual acuity and tenascin C (r+0.605 P<0.001), metaloprotein-1 (r+0.704, P<0.001), BAX, BCL2 (r+0.738, P<0.001),
subfatin and asprosin levels.
CONCLUSIONS: The molecules studied herein were negatively correlated with visual acuity and positively correlated with macular thickness, suggesting that these molecules might have a role in the pathogenesis of CSCR. Thus, we predict that these molecules could be new candidates for the diagnosis and follow-up of CSCR in the future.